Primary gastric tumors of infancy and childhood: 54-year experience at a single institution

被引:21
作者
Curtis, Jennifer L.
Burns, R. Cartland [2 ]
Wang, Larry [3 ]
Mahour, G. Hossein
Ford, Henri R. [1 ]
机构
[1] Childrens Hosp Los Angeles, Div Pediat Surg, Los Angeles, CA 90027 USA
[2] Univ So Calif, Keck Sch Med, Dept Surg, Los Angeles, CA 90089 USA
[3] Univ So Calif, Keck Sch Med, Dept Pathol, Los Angeles, CA 90089 USA
关键词
gastric tumor; stomach; pediatric; surgery;
D O I
10.1016/j.jpedsurg.2007.11.016
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Background/Purpose: Primary gastric tumors are rare in infancy and childhood. Because of the infrequent occurrence of these tumors, the clinician may be Unfamiliar with optimal management strategies. We review our experience over the past 54 years and the current literature. Methods: During the period extending from 1952 to 2006, 21 infants and children with primary gastric tumors were treated at Children's Hospital Los Angeles. The series includes 8 cases previously reported and 13 additional cases seen since the initial report. Follow-up information is included. Results: There were 12 males and 9 females, aged 12 days to 18 years. who were diagnosed with gastric tumors. The patients presented primarily with weight loss, vomiting, or all abdominal mass. Morphological analysis revealed gastric stromal tumors (n = 6), teratomas (n = 4), lymphomas to (n = 4) adenocarcinomas (n = 2), inflammatory myofibroblastic tumors (n = 2), embryonal rhabdomyosarcoma (n = 1), and hamartomas (n = 3). There were 16 patients still alive (mean follow-up, 22.3 months), whereas 6 died from active disease despite multimodal treatment. The deaths occurred in patients with stromal tumors, adenocarcinomas, lymphomas, and rhabdomyosarcoma. Conclusions: Gastric tumors in children are rare. A high index of suspicion is needed to diagnose these tumors. Most malignant tumors present at an advanced stage and carry a substantial rate of mortality. They should be completely resected whenever feasible. In the case of some malignancies, chemotherapy may play a major role. Metastatic evaluation Should be performed in all patients with malignant gastric tumors. (C) 2008 Published by Elsevier Inc.
引用
收藏
页码:1487 / 1493
页数:7
相关论文
共 68 条
  • [1] Staging and preoperative evaluation of upper gastrointestinal malignancies
    Abdalla, EK
    Pisters, PWT
    [J]. SEMINARS IN ONCOLOGY, 2004, 31 (04) : 513 - 529
  • [2] *AJCC, 2002, AJCC CANC STAG MAN
  • [3] GASTRIC LYMPHOMA IN AN 11-YEAR-OLD BOY - A CASE-REPORT
    ASHORN, P
    LAHDE, PL
    RUUSKA, T
    MAKIPERNAA, A
    [J]. MEDICAL AND PEDIATRIC ONCOLOGY, 1994, 22 (01): : 66 - 67
  • [4] Bethel CAI, 1997, J PEDIATR SURG, V32, P1004, DOI 10.1016/S0022-3468(97)90387-0
  • [5] Quality control of lymph node dissection in the Dutch randomized trial of D1 and D2 lymph node dissection for gastric cancer
    J. J Bonenkamp
    J. Hermans
    M. Sasako
    C.J.H. van de Velde
    [J]. Gastric Cancer, 1998, 1 (2) : 152 - 159
  • [6] Malignant gastric teratoma: Case report
    Bourke, CJ
    Mackay, AJ
    Payton, D
    [J]. PEDIATRIC SURGERY INTERNATIONAL, 1997, 12 (2-3) : 192 - 193
  • [7] GASTROINTESTINAL TERATOMAS - CT AND US APPEARANCE WITH PATHOLOGICAL CORRELATION
    BOWEN, B
    ROS, PR
    MCCARTHY, MJ
    OLMSTED, WW
    HJERMSTAD, BM
    [J]. RADIOLOGY, 1987, 162 (02) : 431 - 433
  • [8] Rhabdomyosarcoma: New windows of opportunity
    Breitfeld, PP
    Meyer, WH
    [J]. ONCOLOGIST, 2005, 10 (07) : 518 - 527
  • [9] CHIU KW, 1995, HEPATO-GASTROENTEROL, V42, P367
  • [10] Pediatric inflammatory myofibroblastic tumor: Anaplastic lymphoma kinase (ALK) expression and prognosis
    Chun, YS
    Wang, LN
    Nascimento, AG
    Moir, CR
    Rodeberg, DA
    [J]. PEDIATRIC BLOOD & CANCER, 2005, 45 (06) : 796 - 801