Supplemented amino acids may enhance the walking recovery of elderly subjects after hip fracture surgery

被引：24

作者：

Aquilani, Roberto ^{[1
]}

Ginetto, Carlo Zuccarelli ^{[2
]}

Rutili, Carla ^{[2
]}

Pisano, Pietro ^{[2
]}

Pasini, Evasio ^{[3
]}

Baldissarro, Eleonora ^{[4
]}

Verri, Manuela ^{[1
]}

Boschi, Federica ^{[5
]}

机构：

[1] Univ Pavia, Dipartimento Biol & Biotecnol, Via Ferrata 1, I-27100 Pavia, Italy

[2] Ist Geriatr P Redaelli Reparti Riabilitaz Geriatr, Via Leopardi 3, I-20090 Milan, Italy

[3] IRCCS, Ist Clin Sci Maugeri, Ctr Med Lumezzane, Div Riabilitaz Cardiol, Via G Mazzini 129, I-25065 Lumezzane, BS, Italy

[4] IRCCS, Ist Clin Sci Maugeri, Ctr Med Nervi, Dipartimento Med Fis & Riabilitat, Via Missolungi 14, I-16167 Nervi, GE, Italy

[5] Univ Pavia, Dipartimento Sci Farmaco, Viale Taramelli 14, I-27100 Pavia, Italy

来源：

AGING CLINICAL AND EXPERIMENTAL RESEARCH | 2019年 / 31卷 / 01期

关键词：

Hip fracture; Amino acids; Walking test;

D O I：

10.1007/s40520-018-0941-x

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The purpose of this study was to investigate whether supplemented essential amino acids (EAAs) could enhance rehabilitation therapy (Rehab) for recovery of walking capacity in subjects after hip fracture surgery (HFS). Eighty-three elderly subjects with HFS (20 +/- 11days after acute trauma) were eligible for the study and randomized to receive Rehab only (Rehab; n=27), Rehab+placebo (RP; n=28) or Rehab+EAAs (RE 8g/day; n=28). The patients' walking capacity (m) was measured by 6-min walking distance (6MWD) at admission and at discharge (median 66days after admission). All patient groups were treated with the same Rehab (2sessions/dayx5days/week). The results showed that the gain in 6MWD was higher in RE than in Rehab and RP (p=0.034; p=0.024). The study shows that EAA supplementation can enhance walking recovery rate in subjects with HFS.

引用

页码：157 / 160

页数：4

共 16 条

[1] Despite Inflammation, Supplemented Essential Amino Acids May Improve Circulating Levels of Albumin and Haemoglobin in Patients after Hip Fractures [J].

Aquilani, Roberto ;

Zuccarelli, Ginetto Carlo ;

Condino, Anna Maria ;

Catani, Michele ;

Rutili, Carla ;

Del Vecchio, Consiglia ;

Pisano, Pietro ;

Verri, Manuela ;

Iadarola, Paolo ;

Viglio, Simona ;

Boschi, Federica .

NUTRIENTS, 2017, 9 (06)

[2]

Aquilani R, 2008, EUR J HEART FAIL, V10, P1127, DOI 10.1016/j.ejheart.2008.09.002

[3] The Hip Functional Retrieval after Elective Surgery May Be Enhanced by Supplemented Essential Amino Acids [J].

Baldissarro, Eleonora ;

Aquilani, Roberto ;

Boschi, Federica ;

Baiardi, Paola ;

Iadarola, Paolo ;

Fumagalli, Marco ;

Pasini, Evasio ;

Verri, Manuela ;

Dossena, Maurizia ;

Gambino, Arianna ;

Cammisuli, Sharon ;

Viglio, Simona .

BIOMED RESEARCH INTERNATIONAL, 2016, 2016

[4]

Dal Negro R W, 2012, Monaldi Arch Chest Dis, V77, P67

[5] Generalized linear mixed models: a review and some extensions [J].

Dean, C. B. ;

Nielsen, Jason D. .

LIFETIME DATA ANALYSIS, 2007, 13 (04) :497-512

[6]

Di Monaco M, 2013, EUR J PHYS REHAB MED, V49, P893

[7] Essential amino acid supplementation in patients following total knee arthroplasty [J].

Dreyer, Hans C. ;

Strycker, Lisa A. ;

Senesac, Hilary A. ;

Hocker, Austin D. ;

Smolkowski, Keith ;

Shah, Steven N. ;

Jewett, Brian A. .

JOURNAL OF CLINICAL INVESTIGATION, 2013, 123 (11) :4654-4666

[8] Loss of bone density and lean body mass after hip fracture [J].

Fox, KM ;

Magaziner, J ;

Hawkes, WG ;

Yu-Yahiro, J ;

Hebel, JR ;

Zimmerman, SI ;

Holder, L ;

Michael, R .

OSTEOPOROSIS INTERNATIONAL, 2000, 11 (01) :31-35

[9] Intensive physical training in geriatric patients after severe falls and hip surgery [J].

Hauer, K ;

Specht, N ;

Schuler, M ;

Bärtsch, P ;

Oster, P .

AGE AND AGEING, 2002, 31 (01) :49-57

[10]

Hsieh LC, 2010, ASIA PAC J CLIN NUTR, V19, P200

← 1 2 →