Studies on search for bioactive natural products targeting TRAIL signaling leading to tumor cell apoptosis

被引：91

作者：

Ishibashi, Mastimi ^{[1
]}

Ohtsuki, Takashi ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Pharmaceut Sci, Inage Ku, Chiba 2638522, Japan

来源：

MEDICINAL RESEARCH REVIEWS | 2008年 / 28卷 / 05期

基金：

日本科学技术振兴机构;

关键词：

natural products; TRAIL; apoptosis; Curcuma parviflora; myxomycete;

D O I：

10.1002/med.20123

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induces apoptosis in many transformed cells but not in normal cells and, hence, has been expected as a new anticancer strategy. During our studies on search for bioactive natural products from various natural resources such as plants and microorganisms, we recently indetified several natural products which exhibited activities related to TRAIL signaling. Dimeric sesquiterpenoids isolated from Zingiberaceous plant, Curcuma parviflora, showed enhancement activity of gene expression of TRAIL-receptor and TRAIL-receptor protein level. Several new isoflavone natural products, named brandisianins, were isolated from Leguminosaeous plant. Millettia brandisiana, by our screening study targeting TRAIL-receptor expression enhancement activity. A dihydroflavonol (BB1) that was extracted from Compositaeous plant, Blumea balsamifera, and fuligocandin B, a new anthranilylproline-indole alkaloid isolated from myxomycete were found to exhibit reversal effect of-TRAIL resistance activity. (C) 2008 Wiley Periodicals, Inc.

引用

页码：688 / 714

页数：27