ENO1 and Cancer

被引：115

作者：

Huang, Chen Kai ^{[1
]}

Sun, Ying ^{[2
]}

Lv, Lei ^{[3
]}

Ping, Yong ^{[4
]}

机构：

[1] Univ Calif Berkeley, Dept Mol & Cellular Biol, 110 Sproul Hall, Berkeley, CA 94720 USA

[2] Shanghai Jiao Tong Univ, Dept Immunol & Microbiol, Sch Med, South Chongqing Rd 225, Shanghai, Peoples R China

[3] Fudan Univ, MOE Key Lab Metab & Mol Med, Dept Biochem & Mol Biol, Sch Basic Med Sci, Shanghai 200032, Peoples R China

[4] Shanghai Jiao Tong Univ, Minist Educ, Bio X Inst, Key Lab Genet Dev & Neuropsychiat Disorders, Shanghai 200240, Peoples R China

来源：

MOLECULAR THERAPY ONCOLYTICS | 2022年 / 24卷

关键词：

ANTI-ALPHA-ENOLASE; LUNG-CANCER; PROTEOMIC ANALYSIS; DOWN-REGULATION; T-CELLS; EXPRESSION; GLYCOLYSIS; IDENTIFICATION; CARCINOMA; AUTOANTIBODIES;

D O I：

10.1016/j.omto.2021.12.026

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

alpha-Enolase (ENO1), also known as 2-phospho-D-glycerate hydrolase, is a glycolytic enzyme that catalyzes the conversion of 2-phosphoglyceric acid to phosphoenolpyruvic acid during glycolysis. It is a multifunctional oncoprotein that is present both in cell surface and cytoplasm, contributing to hit seven out of ten "hallmarks of cancer." ENO1's glycolytic function deregulates cellular energetic, sustains tumor proliferation, and inhibits cancer cell apoptosis. Moreover, ENO1 evades growth suppressors and helps tumors to avoid immune destruction. Besides, ENO1 "moonlights" on the cell surface and acts as a plasminogen receptor, promoting cancer invasion and metastasis by inducing angiogenesis. Overexpression of ENO1 on a myriad of cancer types together with its localization on the tumor surface makes it a great prognostic and diagnostic cancer biomarker as well as an accessible oncotherapeutic target. This review summarizes the up-to-date knowledge about the relationship between ENO1 and cancer, examines ENO1's potential as a cancer biomarker, and discusses ENO1's role in novel onco-immunotherapeutic strategies.

引用

页码：288 / 298

页数：11

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