ENO1 and Cancer

被引：89
作者：
Huang, Chen Kai [1 ]
Sun, Ying [2 ]
Lv, Lei [3 ]
Ping, Yong [4 ]
机构：
[1] Univ Calif Berkeley, Dept Mol & Cellular Biol, 110 Sproul Hall, Berkeley, CA 94720 USA
[2] Shanghai Jiao Tong Univ, Dept Immunol & Microbiol, Sch Med, South Chongqing Rd 225, Shanghai, Peoples R China
[3] Fudan Univ, MOE Key Lab Metab & Mol Med, Dept Biochem & Mol Biol, Sch Basic Med Sci, Shanghai 200032, Peoples R China
[4] Shanghai Jiao Tong Univ, Minist Educ, Bio X Inst, Key Lab Genet Dev & Neuropsychiat Disorders, Shanghai 200240, Peoples R China
来源：
MOLECULAR THERAPY ONCOLYTICS | 2022年 / 24卷
关键词：
ANTI-ALPHA-ENOLASE; LUNG-CANCER; PROTEOMIC ANALYSIS; DOWN-REGULATION; T-CELLS; EXPRESSION; GLYCOLYSIS; IDENTIFICATION; CARCINOMA; AUTOANTIBODIES;
D O I：
10.1016/j.omto.2021.12.026
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
alpha-Enolase (ENO1), also known as 2-phospho-D-glycerate hydrolase, is a glycolytic enzyme that catalyzes the conversion of 2-phosphoglyceric acid to phosphoenolpyruvic acid during glycolysis. It is a multifunctional oncoprotein that is present both in cell surface and cytoplasm, contributing to hit seven out of ten "hallmarks of cancer." ENO1's glycolytic function deregulates cellular energetic, sustains tumor proliferation, and inhibits cancer cell apoptosis. Moreover, ENO1 evades growth suppressors and helps tumors to avoid immune destruction. Besides, ENO1 "moonlights" on the cell surface and acts as a plasminogen receptor, promoting cancer invasion and metastasis by inducing angiogenesis. Overexpression of ENO1 on a myriad of cancer types together with its localization on the tumor surface makes it a great prognostic and diagnostic cancer biomarker as well as an accessible oncotherapeutic target. This review summarizes the up-to-date knowledge about the relationship between ENO1 and cancer, examines ENO1's potential as a cancer biomarker, and discusses ENO1's role in novel onco-immunotherapeutic strategies.
引用
收藏
页码：288 / 298
页数：11
相关论文
共 90 条
  • [1] Alpha-Enolase: Emerging Tumor-Associated Antigen, Cancer Biomarker, and Oncotherapeutic Target
    Almaguel, Frankis A.
    Sanchez, Tino W.
    Ortiz-Hernandez, Greisha L.
    Casiano, Carlos A.
    [J]. FRONTIERS IN GENETICS, 2021, 11
  • [2] Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes
    Altenberg, B
    Greulich, KO
    [J]. GENOMICS, 2004, 84 (06) : 1014 - 1020
  • [3] The interaction between bacterial enolase and plasminogen promotes adherence of Streptococcus pneumoniae to epithelial and endothelial cells
    Bergmann, Simone
    Schoenen, Hanne
    Hammerschmidt, Sven
    [J]. INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, 2013, 303 (08) : 452 - 462
  • [4] Expression of Alpha-Enolase (ENO1), Myc Promoter-Binding Protein-1 (MBP-1) and Matrix Metalloproteinases (MMP-2 and MMP-9) Reflect the Nature and Aggressiveness of Breast Tumors
    Cancemi, Patrizia
    Buttacavoli, Miriam
    Roz, Elena
    Feo, Salvatore
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (16)
  • [5] Targeting the Warburg effect in cancer cells through ENO1 knockdown rescues oxidative phosphorylation and induces growth arrest
    Capello, Michela
    Ferri-Borgogno, Sammy
    Riganti, Chiara
    Chattaragada, Michelle Samuel
    Principe, Moitza
    Roux, Cecilia
    Zhou, Weidong
    Petricoin, Emanuel F.
    Cappello, Paola
    Novelli, Francesco
    [J]. ONCOTARGET, 2016, 7 (05) : 5598 - 5612
  • [6] α-enolase: a promising therapeutic and diagnostic tumor target
    Capello, Michela
    Ferri-Borgogno, Sammy
    Cappello, Paola
    Novelli, Francesco
    [J]. FEBS JOURNAL, 2011, 278 (07) : 1064 - 1074
  • [7] Next Generation Immunotherapy for Pancreatic Cancer: DNA Vaccination is Seeking New Combo Partners
    Cappello, Paola
    Curcio, Claudia
    Mandili, Giorgia
    Roux, Cecilia
    Bulfamante, Sara
    Novelli, Francesco
    [J]. CANCERS, 2018, 10 (02):
  • [8] Vaccination With ENO1 DNA Prolongs Survival of Genetically Engineered Mice With Pancreatic Cancer
    Cappello, Paola
    Rolla, Simona
    Chiarle, Roberto
    Principe, Moitza
    Cavallo, Federica
    Perconti, Giovanni
    Feo, Salvatore
    Giovarelli, Mirella
    Novelli, Francesco
    [J]. GASTROENTEROLOGY, 2013, 144 (05) : 1098 - 1106
  • [9] Three are better than one: Plasminogen receptors as cancer theranostic targets
    Ceruti P.
    Principe M.
    Capello M.
    Cappello P.
    Novelli F.
    [J]. Experimental Hematology & Oncology, 2 (1)
  • [10] Identification of α-enolase as an autoantigen in lung cancer:: Its overexpression is associated with clinical outcomes
    Chang, Gee-Chen
    Liu, Ko-Jiunn
    Hsieh, Chia-Ling
    Hu, Tsai-Shu
    Charoenfuprasert, Suparat
    Liu, Hsiung-Kun
    Luh, Kwen-Tay
    Hsu, Li-Han
    Wu, Chew-Wen
    Ting, Chou-Chik
    Chen, Chih-Yi
    Chen, Kun-Chieh
    Yang, Tsung-Ying
    Chou, Teh-Ying
    Wang, Wen-Hua
    Whang-Peng, Jacqueline
    Shih, Neng-Yao
    [J]. CLINICAL CANCER RESEARCH, 2006, 12 (19) : 5746 - 5754
123456789