Translating data from animal models into methods for preventing human autoimmune diabetes mellitus:: Caveat emptor and primum non nocere

被引：52

作者：

Greiner, DL ^{[1
]}

Rossini, AA ^{[1
]}

Mordes, JP ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01655 USA

来源：

CLINICAL IMMUNOLOGY | 2001年 / 100卷 / 02期

关键词：

D O I：

10.1006/clim.2001.5075

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Type 1 diabetes in humans is a serious autoimmune disorder of children that is still poorly understood unpreventable, and irreversible. Study of its animal models, notably the NOD mouse and BB rat, has generated a wealth of information concerning genetics and immunopathogenesis, but that information has still not altered the way in which we treat children with diabetes. In this review we attempt to identify the most promising avenues of continuing research in these models and the most important issues that must be faced by the designers of human therapies based on the animal dataset. (C) 2001 Academic Press.

引用

页码：134 / 143

页数：10

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