The roles of oxidized low-density lipoprotein and interleukin-6 levels in acute atherothrombotic and lacunar ischemic stroke

被引：22

作者：

Guldiken, Baburhan ^{[1
]}

Guldiken, Sibel ^{[2
]}

Turgut, Burhan ^{[3
]}

Turgut, Nilda ^{[4
]}

Demir, Muzaffer ^{[3
]}

Celik, Yahya ^{[4
]}

Arikan, Ender ^{[2
]}

Tugrul, Armagan ^{[2
]}

机构：

[1] Trakya Univ, Fac Med, Social Secur Hosp, Dept Neurol, Edirne, Turkey

[2] Trakya Univ, Fac Med, Dept Endocrinol, Edirne, Turkey

[3] Trakya Univ, Fac Med, Dept Hematol, Edirne, Turkey

[4] Trakya Univ, Fac Med, Dept Neurol, Edirne, Turkey

来源：

ANGIOLOGY | 2008年 / 59卷 / 02期

关键词：

ischemic stroke; oxidized low-density lipoprotein; interleukin-6; atherosclerosis;

D O I：

10.1177/0003319707304134

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

The role of circulating, oxidized low-density lipoprotein and interleukin-6 levels in acute ischemic stroke considering the primary-vessel disease was investigated. The study consisted of 28 patients with acute ischemic stroke and 23 control subjects. Patients were subdivided into large-vessel (n = 12) and small-vessel (n = 16) disease stroke groups according to the Trial of Org 10172 in Acute Stroke Treatment (TOAST) criteria. The means of oxidized low-density lipoprotein and interleukin-6 levels of patients with acute ischemic stroke were higher than controls (P < .01, P < .05). Mean oxidized low-density lipoprotein level was higher in the large-vessel disease group than in the small-vessel disease group (P < .01). The mean of inteleukin-6 levels was higher in the small-vessel disease group (P < .01). The results of the present study showed that oxidative stress promotes large-vessel disease rather than small-vessel disease stroke, and inflammation may play important an role in the development of small-vessel disease stroke.

引用

页码：224 / 229

页数：6

共 25 条

[1] CLASSIFICATION OF SUBTYPE OF ACUTE ISCHEMIC STROKE - DEFINITIONS FOR USE IN A MULTICENTER CLINICAL-TRIAL [J].

ADAMS, HP ;

BENDIXEN, BH ;

KAPPELLE, LJ ;

BILLER, J ;

LOVE, BB ;

GORDON, DL ;

MARSH, EE ;

KASE, CS ;

WOLF, PA ;

BABIKIAN, VL ;

LICATAGEHR, EE ;

ALLEN, N ;

BRASS, LM ;

FAYAD, PB ;

PAVALKIS, FJ ;

WEINBERGER, JM ;

TUHRIM, S ;

RUDOLPH, SH ;

HOROWITZ, DR ;

BITTON, A ;

MOHR, JP ;

SACCO, RL ;

CLAVIJO, M ;

ROSENBAUM, DM ;

SPARR, SA ;

KATZ, P ;

KLONOWSKI, E ;

CULEBRAS, A ;

CAREY, G ;

MARTIR, NI ;

FICARRA, C ;

HOGAN, EL ;

CARTER, T ;

GURECKI, P ;

MUNTZ, BK ;

RAMIREZLASSEPAS, M ;

TULLOCH, JW ;

QUINONES, MR ;

MENDEZ, M ;

ZHANG, SM ;

ALA, T ;

JOHNSTON, KC ;

ANDERSON, DC ;

TARREL, RM ;

NANCE, MA ;

BUDLIE, SR ;

DIERICH, M ;

HELGASON, CM ;

HIER, DB ;

SHAPIRO, RA .

STROKE, 1993, 24 (01) :35-41

[2]

BENEVISTE EN, 1992, AM J PHYSIOL, V263, pC1

[3] Inflammation-mediated damage in progressing lacunar infarctions -: A potential therapeutic target [J].

Castellanos, M ;

Castillo, J ;

García, MM ;

Leira, R ;

Serena, J ;

Chamorro, A ;

Dávalos, A .

STROKE, 2002, 33 (04) :982-987

[4] Elevated levels of oxidized low density lipoprotein show a positive relationship with the severity of acute coronary syndromes [J].

Ehara, S ;

Ueda, M ;

Naruko, T ;

Haze, K ;

Itoh, A ;

Otsuka, M ;

Komatsu, R ;

Matsuo, T ;

Itabe, H ;

Takano, T ;

Tsukamoto, Y ;

Yoshiyama, M ;

Takeuchi, K ;

Yoshikawa, J ;

Becker, AE .

CIRCULATION, 2001, 103 (15) :1955-1960

[5] PROINFLAMMATORY CYTOKINES IN SERUM OF PATIENTS WITH ACUTE CEREBRAL-ISCHEMIA - KINETICS OF SECRETION AND RELATION TO THE EXTENT OF BRAIN-DAMAGE AND OUTCOME OF DISEASE [J].

FASSBENDER, K ;

ROSSOL, S ;

KAMMER, T ;

DAFFERTSHOFER, M ;

WIRTH, S ;

DOLLMAN, M ;

HENNERICI, M .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1994, 122 (02) :135-139

[6] Adhesion molecules in cerebrovascular diseases -: Evidence for an inflammatory endothelial activation in cerebral large- and small-vessel disease [J].

Fassbender, K ;

Bertsch, T ;

Mielke, O ;

Mühlhauser, F ;

Hennerici, M .

STROKE, 1999, 30 (08) :1647-1650

[7] Status of lipids as a risk factor for stroke [J].

Gorelick, PB ;

Schneck, M ;

Berglund, LF ;

Feinberg, W ;

Goldstone, J .

NEUROEPIDEMIOLOGY, 1997, 16 (03) :107-115

[8] Circulating oxidized LDL is associated with subclinical atherosclerosis development and inflammatory cytokines (AIR study) [J].

Hulthe, J ;

Fagerberg, B .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2002, 22 (07) :1162-1167

[9]

Jialal I, 1998, CLIN CHEM, V44, P1827

[10] Low plasma antioxidant activity is associated with high lesion volume and neurological impairment in stroke [J].

Leinonen, JS ;

Ahonen, JP ;

Lönnrot, K ;

Jehkonen, M ;

Dastidar, P ;

Molnár, G ;

Alho, H .

STROKE, 2000, 31 (01) :33-39

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