Atovaquone/proguanil resistance in Africa: a case report

被引：31
作者：
David, KP
Alifrangis, M
Salanti, A
Vestergaard, LS
Ronn, A
Bygbjerg, I
机构：
[1] Rigshosp, Dept Infect Dis, DK-2100 Copenhagen, Denmark
[2] Univ Copenhagen, Inst Publ Hlth, Dept Int Hlth, DK-1168 Copenhagen, Denmark
来源：
SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES | 2003年 / 35卷 / 11-12期
关键词：
D O I：
10.1080/00365540310016862
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
The Atovaquone/proguanil combination has quickly been established as an effective chemoprophylaxis for travellers to areas with chloroquineresistant Plasmodium falciparum malaria. We describe the molecular cause of the first reported case of primary Atovaquone/proguanil resistance observed in our department in a Plasmodium falciparum infected traveller returning from West Africa, and link our findings to other reports of resistance.
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页码：897 / 898
页数：2
相关论文
共 9 条
[1]  
Djimdé A, 2001, NEW ENGL J MED, V344, P257, DOI 10.1056/NEJM200101253440403
[2]  
FIVELMA Q, 2000, MALAR J, V1, P1
[3]   Atovaquone-proguanil versus chloroquine-proguanil for malaria prophylaxis in non-immune travellers:: a randomised, double-blind study [J].
Hogh, B ;
Clarke, PD ;
Camus, D ;
Nothdurft, HD ;
Overbosch, D ;
Günther, M ;
Joubert, I ;
Kain, KC ;
Shaw, D ;
Roskell, NS ;
Chulay, JD .
LANCET, 2000, 356 (9245) :1888-1894
[4]   Mutations in Plasmodium falciparum cytochrome b that are associated with atovaquone resistance are located at a putative drug-binding site [J].
Korsinczky, M ;
Chen, NH ;
Kotecka, B ;
Saul, A ;
Rieckmann, K ;
Cheng, Q .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (08) :2100-2108
[5]   Clinical studies of atovaquone, alone or in combination with other antimalarial drugs, for treatment of acute uncomplicated malaria in Thailand [J].
Looareesuwan, S ;
Viravan, C ;
Webster, HK ;
Kyle, DE ;
Canfield, CJ .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1996, 54 (01) :62-66
[6]   Kenyan Plasmodium falciparum field isolates:: Correlation between pyrimethamine and chlorcycloguanil activity in vitro and point mutations in the dihydrofolate reductase domain [J].
Nzila-Mounda, A ;
Mberu, EK ;
Sibley, CH ;
Plowe, CV ;
Winstanley, PA ;
Watkins, WM .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (01) :164-169
[7]   Atovaquone-proguanil versus mefloquine for malaria prophylaxis in nonimmune travelers: Results from a randomized, double-blind study [J].
Overbosch, D ;
Schilthuis, H ;
Bienzle, U ;
Behrens, RH ;
Kain, KC ;
Clarke, PD ;
Toovey, S ;
Knobloch, J ;
Nothdurft, HD ;
Shaw, D ;
Roskell, NS ;
Chulay, JD .
CLINICAL INFECTIOUS DISEASES, 2001, 33 (07) :1015-1021
[8]   Different mutation patterns of atovaquone resistance to Plasmodium falciparum in vitro and in vivo:: rapid detection of codon 268 polymorphisms in the cytochrome b as potential in vivo resistance marker -: art. no. 5 [J].
Schwöbel, B ;
Alifrangis, M ;
Salanti, A ;
Jelinek, T .
MALARIA JOURNAL, 2003, 2 (1)
[9]   Epidemiology of drug-resistant malaria [J].
Wongsrichanalai, C ;
Pickard, AL ;
Wernsdorfer, WH ;
Meshnick, SR .
LANCET INFECTIOUS DISEASES, 2002, 2 (04) :209-218
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