Phytochemical study and evaluation of the molluscicidal activity of Calophyllum brasiliense CAMB (Clusiaceae).

被引：32

作者：

Gasparotto, A

Brenzan, MA

Piloto, IC

Cortez, DA

Nakamura, CV

Dias, BP

Rodrigues, E

Ferreira, AG

机构：

[1] Univ Estadual Maringa, Dept Farm & Farmacol, BR-87020900 Maringa, Parana, Brazil

[2] Univ Estadual Maringa, Dept Anal Clin, BR-87020900 Maringa, Parana, Brazil

[3] Univ Fed Sao Carlos, Dept Quim, BR-13560970 Sao Carlos, SP, Brazil

来源：

QUIMICA NOVA | 2005年 / 28卷 / 04期

关键词：

Calophyllum brasiliense; molluscicidal activity; coumarin;

D O I：

10.1590/S0100-40422005000400003

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The bioassay-guided fractionation against Biomphalaria glabrata of hydroalcoholic extracts of Calophyllum brasiliense aerial parts led to the isolation of the coumarin, named (-) mammea A/BB. The compound had its structure determined by both spectroscopic techniques (NMR H-1, NMR C-13, gHSQC, g-HMBC and MS) and some literature comparison data. The probit analysis of (-) mammea A/BB showed LD50 = 0.67 ppm and LD90 = 1.47 ppm. In addition, the dichloromethane extract obtained from C. brasiliense leaves with significant molluscicidal activity against Biomphalaria glabrata was analyzed by HPLC-UV.

引用

页码：575 / 578

页数：4

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