Quantitative PET measurements of regional myocardial blood flow: Observations in humans with ischemic heart disease

被引：27
作者：
Gewirtz, H
Skopicki, HA
Abraham, SA
Castano, H
Dinsmore, RE
Alpert, NM
Fischman, AJ
机构：
[1] MASSACHUSETTS GEN HOSP,DEPT RADIOL,DIV NUCL MED,BOSTON,MA 02114
[2] HARVARD UNIV,SCH MED,BOSTON,MA
来源：
CARDIOLOGY | 1997年 / 88卷 / 01期
关键词：
PET; myocardial blood flow and flow reserve; ischemic heart disease; myocardial blood flow heterogeneity; POSITRON-EMISSION TOMOGRAPHY; CORONARY-ARTERY DISEASE; N-13; AMMONIA; NONINVASIVE QUANTIFICATION; SPATIAL HETEROGENEITY; RESERVE; PERFUSION; SEVERITY; ARTERIOGRAPHY; STENOSIS;
D O I：
10.1159/000177312
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
This review focuses on several related issues concerning positron emission tomography measurements of regional myocardial blood flow using 13-N-ammonia in humans. The effect of partial volume correction on estimates of KI, the model parameter describing myocardial blood flow, is considered, In addition a new method for computing K1 images of myocardial flow distribution is briefly described and compared to a standard method. Potential differences between K1 and equilibrium levels of 13-N-ammonia in the myocardium for estimation of myocardial blood flow are discussed also. The issue of heterogeneity of myocardial blood flow and flow reserve in normal volunteers is considered from the clinical point of view in terms of evaluation of patients with ischemic heart disease. Finally, the use of absolute measurement of adenosine-stimulated myocardial blood flow to assess physiological significance of coronary artery stenoses is addressed.
引用
收藏
页码：62 / 70
页数：9
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