Normal Free Interleukin-18 ( IL-18) Plasma Levels in Dengue Virus Infection and the Need To Measure Both Total IL-18 and IL-18 Binding Protein Levels

被引：28

作者：

Michels, Meta ^{[1
]}

de Mast, Quirijn ^{[1
]}

Netea, Mihai G. ^{[1
]}

Joosten, Leo A. ^{[1
]}

Dinarello, Charles A. ^{[1
]}

Rudiman, Pandji I. F. ^{[2
]}

Sinarta, Sylvia ^{[2
]}

Wisaksana, Rudi ^{[2
]}

Alisjahbana, Bachti ^{[2
]}

van der Ven, Andre J. A. M. ^{[1
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Internal Med, NL-6525 ED Nijmegen, Netherlands

[2] Padjadjaran State Univ, Fac Med, Dept Internal Med, Bandung, Indonesia

来源：

CLINICAL AND VACCINE IMMUNOLOGY | 2015年 / 22卷 / 06期

基金：

美国国家卫生研究院;

关键词：

HEMORRHAGIC-FEVER; HOST-RESISTANCE; IFN-GAMMA; PATHOGENESIS; ACTIVATION; DISEASE;

D O I：

10.1128/CVI.00147-15

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Activated monocytes/macrophages and T lymphocytes that produce a cytokine storm are assumed to play a pivotal role in the pathogenesis of dengue. Interleukin-18 (IL-18) is a proinflammatory cytokine that is increased during dengue and known to induce gamma interferon (IFN-gamma), which is crucial for dengue immune response. No data are available regarding the balance between IL-18 and its natural inhibitor IL-18 binding protein (IL-18BP) and how they interact within the inflammatory reaction of patients with dengue virus infections. Circulating levels of IL-18; IL-18BP; free, biologically active IL-18; the IL-18-dependent proinflammatory cytokine IFN-gamma; monocyte-derived cytokines; and ferritin were assessed in adult Indonesian dengue patients (n = 95). Healthy individuals (n = 22) and leptospirosis (n = 19) and enteric fever (n = 6) patients served as controls. Total IL-18 levels were increased during dengue, leptospirosis, and enteric fever compared to healthy controls. However, due to a concurrent increase in IL-18BP levels, biologically active IL-18 levels remained similar in the different phases of dengue and in patients with leptospirosis. Biologically active IL-18 levels were also similar in patients with severe and nonsevere dengue. In conclusion, high total IL-18 and IL-18BP levels concur in dengue virus infections, leptospirosis, and enteric fever. This resulted in unchanged levels of free, biologically active IL-18 in dengue and leptospirosis, which underlines the importance of measuring both IL-18 and IL-18BP when studying the role of IL-18 in diseases.

引用

页码：650 / 655

页数：6

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