In vitro models for assessing therapeutic angiogenesis

被引:23
作者
Sanz-Nogues, Clara [1 ]
O'Brien, Timothy [1 ]
机构
[1] Natl Univ Ireland Galway, Regenerat Med Inst REMEDI, Biomed Sci Bldg,Newcastle Rd, Galway, Ireland
关键词
MESENCHYMAL STEM-CELLS; HUMAN ENDOTHELIAL PROGENITOR; NEOVASCULARIZATION CAPACITY; 3-DIMENSIONAL COLLAGEN; PROTEOMIC ANALYSIS; LIMB ISCHEMIA; EXPRESSION; MIGRATION; ASSAY; INVASION;
D O I
10.1016/j.drudis.2016.05.016
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Arterial obstruction leading to ischemia causes a reduction of oxygen and nutrient supply to distal tissues. The physiological response to tissue ischemia triggers a cascade of events that results in the development of accessory vasculature to increase local tissue perfusion and to salvage tissue. However, this adaptive mechanism of repair is suboptimal in some patients. Therapeutic angiogenesis aims to stimulate new blood vessel formation via the local administration of proangiogenic agents or cell therapy products (CTPs). In this review, we provide a summary of the current understanding of in vitro models for assessing the angiogenic potential of a product.
引用
收藏
页码:1495 / 1503
页数:9
相关论文
共 74 条
  • [21] Comparison of three in vitro human 'angiogenesis' assays with capillaries formed in vivo
    Donovan D.
    Brown N.J.
    Bishop E.T.
    Lewis C.E.
    [J]. Angiogenesis, 2001, 4 (2) : 113 - 121
  • [22] Duffy GP, 2009, TISSUE ENG PT A, V15, P2459, DOI [10.1089/ten.tea.2008.0341, 10.1089/ten.TEA.2008.0341]
  • [23] Duscher D., 2015, GERONTOLOGY, VXX, P1
  • [24] Duttenhoefer F, 2013, EUR CELLS MATER, V26, P49
  • [25] Neovascularization Capacity of Mesenchymal Stromal Cells From Critical Limb Ischemia Patients Is Equivalent to Healthy Controls
    Gremmels, Hendrik
    Teraa, Martin
    Quax, Paul H. A.
    den Ouden, Krista
    Fledderus, Joost
    Verhaar, Marianne C.
    [J]. MOLECULAR THERAPY, 2014, 22 (11) : 1960 - 1970
  • [26] Scaffold-free tissue engineering using cell sheet technology
    Haraguchi, Yuji
    Shimizu, Tatsuya
    Yamato, Masayuki
    Okano, Teruo
    [J]. RSC ADVANCES, 2012, 2 (06): : 2184 - 2190
  • [27] Profoundly reduced neovascularization capacity of bone marrow mononuclear cells derived from patients with chronic ischemic heart disease
    Heeschen, C
    Lehmann, R
    Honold, J
    Assmus, B
    Aicher, A
    Walter, DH
    Martin, H
    Zeiher, AM
    Dimmeler, S
    [J]. CIRCULATION, 2004, 109 (13) : 1615 - 1622
  • [28] Exosomes secreted by human-induced pluripotent stem cell-derived mesenchymal stem cells attenuate limb ischemia by promoting angiogenesis in mice
    Hu, Guo-wen
    Li, Qing
    Niu, Xin
    Hu, Bin
    Liu, Juan
    Zhou, Shu-min
    Guo, Shang-chun
    Lang, Hai-li
    Zhang, Chang-qing
    Wang, Yang
    Deng, Zhi-feng
    [J]. STEM CELL RESEARCH & THERAPY, 2015, 6
  • [29] Exosomes in Mesenchymal Stem Cells, a New Therapeutic Strategy for Cardiovascular Diseases?
    Huang, Lina
    Ma, Wenya
    Ma, Yidi
    Feng, Dan
    Chen, Hongyang
    Cai, Benzhi
    [J]. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2015, 11 (02): : 238 - 245
  • [30] Human microvascular endothelial cells differ from macrovascular endothelial cells in their expression of matrix metalloproteinases
    Jackson, CJ
    Nguyen, M
    [J]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 1997, 29 (10) : 1167 - 1177