In vitro models for assessing therapeutic angiogenesis

被引：23
作者：
Sanz-Nogues, Clara [1 ]
O'Brien, Timothy [1 ]
机构：
[1] Natl Univ Ireland Galway, Regenerat Med Inst REMEDI, Biomed Sci Bldg,Newcastle Rd, Galway, Ireland
来源：
DRUG DISCOVERY TODAY | 2016年 / 21卷 / 09期
关键词：
MESENCHYMAL STEM-CELLS; HUMAN ENDOTHELIAL PROGENITOR; NEOVASCULARIZATION CAPACITY; 3-DIMENSIONAL COLLAGEN; PROTEOMIC ANALYSIS; LIMB ISCHEMIA; EXPRESSION; MIGRATION; ASSAY; INVASION;
D O I：
10.1016/j.drudis.2016.05.016
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Arterial obstruction leading to ischemia causes a reduction of oxygen and nutrient supply to distal tissues. The physiological response to tissue ischemia triggers a cascade of events that results in the development of accessory vasculature to increase local tissue perfusion and to salvage tissue. However, this adaptive mechanism of repair is suboptimal in some patients. Therapeutic angiogenesis aims to stimulate new blood vessel formation via the local administration of proangiogenic agents or cell therapy products (CTPs). In this review, we provide a summary of the current understanding of in vitro models for assessing the angiogenic potential of a product.
引用
收藏
页码：1495 / 1503
页数：9
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