The Emerging Role of Vascular Endothelial Growth Factor (VEGF) in Vascular Homeostasis: Lessons from Recent Trials with Anti-VEGF Drugs

被引：25

作者：

Thanigaimani, Shivshankar ^{[2
]}

Kichenadasse, Ganessan ^{[3
]}

Mangoni, Arduino A. ^{[1
,2
]}

机构：

[1] Univ Aberdeen, Sch Med & Dent, Div Appl Med, Sect Translat Med Sci, Aberdeen AB25 2ZD, Scotland

[2] Flinders Univ S Australia, Dept Clin Pharmacol, Adelaide, SA, Australia

[3] Flinders Med Ctr, Dept Med Oncol, Adelaide, SA, Australia

来源：

CURRENT VASCULAR PHARMACOLOGY | 2011年 / 9卷 / 03期

关键词：

Vascular endothelial growth factor; angiogenesis; endothelium; homeostasis; cardiotoxicity; hypertension; nitric oxide; clinical trials; PHASE-II TRIAL; TYROSINE KINASE INHIBITOR; ACTIVATED PROTEIN-KINASE; FOCAL ADHESION KINASE; NITRIC-OXIDE SYNTHASE; RENAL-CELL CARCINOMA; METASTATIC COLORECTAL-CANCER; ADVANCED SOLID TUMORS; NF-KAPPA-B; PACLITAXEL PLUS BEVACIZUMAB;

D O I：

10.2174/157016111795495503

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Vascular endothelial growth factor (VEGF) is an endogenous polypeptide that modulates angiogenesis in normal physiological conditions as well as in cancer. During angiogenesis, VEGF interacts with several other angiogenic factors, playing an important role in cell proliferation, differentiation, migration, cell survival, nitric oxide (NO) production, release of other growth factors and sympathetic innervation. Based on these mechanisms of action, several anti-VEGF drugs have been developed for cancer treatment. This review discusses the physiology and interactions of VEGF, its mechanisms of action and role in modulating vascular homeostasis. It also discusses the adverse cardiovascular effects of recently developed anti-VEGF drugs for the treatment of various types of cancer. A critical appraisal of the human studies on these drugs is provided. Furthermore, putative mechanisms for the onset of hypertension, the most common adverse cardiovascular effect, are discussed.

引用

页码：358 / 380

页数：23

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