11β-Hydroxysteroid Dehydrogenase Type 1 as a Potential Treatment Target in Cardiovascular Diseases

被引：7

作者：

Kupczyk, Daria ^{[1
]}

Studzinska, Renata ^{[2
]}

Kolodziejska, Renata ^{[1
]}

Baumgart, Szymon ^{[2
]}

Modrzejewska, Martyna ^{[1
]}

Wozniak, Alina ^{[1
]}

机构：

[1] Nicolaus Copernicus Univ Torun, Coll Med Bydgoszcz, Fac Med, Dept Med Biol & Biochem, Karlowicza 24, PL-85092 Bydgoszcz, Poland

[2] Nicolaus Copernicus Univ Torun, Coll Med Bydgoszcz, Fac Pharm, Dept Organ Chem, Jurasza 2, PL-85089 Bydgoszcz, Poland

来源：

JOURNAL OF CLINICAL MEDICINE | 2022年 / 11卷 / 20期

关键词：

11 beta-hydroxysteroid dehydrogenase; glucocorticoids; metabolic syndrome; cardiovascular diseases; 11 beta-HSD1 selective inhibitors; BETA-HYDROXYSTEROID DEHYDROGENASE; SUBCUTANEOUS ADIPOSE-TISSUE; METABOLIC-SYNDROME; CORTISOL METABOLISM; GLUCOCORTICOID METABOLISM; BIOLOGICAL EVALUATION; 11-BETA-HSD1; INHIBITORS; SELECTIVE INHIBITORS; CUSHINGS-SYNDROME; VISCERAL OBESITY;

D O I：

10.3390/jcm11206190

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Glucocorticoids (GCs) belong to the group of steroid hormones. Their representative in humans is cortisol. GCs are involved in most physiological processes of the body and play a significant role in important biological processes, including reproduction, growth, immune responses, metabolism, maintenance of water and electrolyte balance, functioning of the central nervous system and the cardiovascular system. The availability of cortisol to the glucocorticoid receptor is locally controlled by the enzyme 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1). Evidence of changes in intracellular GC metabolism in the pathogenesis of obesity, metabolic syndrome (MetS) and cardiovascular complications highlights the role of selective 11 beta-HSD1 inhibition in the pharmacotherapy of these diseases. This paper discusses the role of 11 beta-HSD1 in MetS and its cardiovascular complications and the importance of selective inhibition of 11 beta-HSD1.

引用

页数：19

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