Analysis of protein targets in pathogen-host interaction in infectious diseases: a case study on Plasmodium falciparum and Homo sapiens interaction network

被引:22
|
作者
Saha, Sovan [2 ]
Sengupta, Kaustav [3 ]
Chatterjee, Piyali [1 ]
Basu, Subhadip [3 ]
Nasipuri, Mita [3 ]
机构
[1] Netaji Subhash Engn Coll, Dept Comp Sci & Engn, Kolkata 700152, India
[2] Dr Sudhir Chandra Degree Engn Coll, Comp Sci & Engn, Kolkata, India
[3] Jadavpur Univ, Dept Comp Sci & Engn, Kolkata, India
关键词
infectious disease; malaria; pathogen-host interaction; protein interaction network; Bait; Prey; FUNCTION PREDICTION; CENTRALITY; ALGORITHM; BIOLOGY;
D O I
10.1093/bfgp/elx024
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Infection and disease progression is the outcome of protein interactions between pathogen and host. Pathogen, the role player of Infection, is becoming a severe threat to life as because of its adaptability toward drugs and evolutionary dynamism in nature. Identifying protein targets by analyzing protein interactions between host and pathogen is the key point. Proteins with higher degree and possessing some topologically significant graph theoretical measures are found to be drug targets. On the other hand, exceptional nodes may be involved in infection mechanism because of some pathway process and biologically unknown factors. In this article, we attempt to investigate characteristics of host-pathogen protein interactions by presenting a comprehensive review of computational approaches applied on different infectious diseases. As an illustration, we have analyzed a case study on infectious disease malaria, with its causative agent Plasmodium falciparum acting as 'Bait' and host, Homo sapiens/human acting as 'Prey'. In this pathogen-host interaction network based on some interconnectivity and centrality properties, proteins are viewed as central, peripheral, hub and non-hub nodes and their significance on infection process. Besides, it is observed that because of sparseness of the pathogen and host interaction network, there may be some topologically unimportant but biologically significant proteins, which can also act as Bait/Prey. So, functional similarity or gene ontology mapping can help us in this case to identify these proteins.
引用
收藏
页码:441 / 450
页数:10
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