New preventive strategies for respiratory syncytial virus infection in children

被引：6

作者：

Glowinski, Rebecca ^{[1
,2
]}

Mejias, Asuncion ^{[1
,2
,3
,4
,5
]}

Ramilo, Octavio ^{[1
,2
,3
,4
]}

机构：

[1] Nationwide Childrens Hosp, Ctr Vaccines & Immun, Abigail Wexner Res Inst, Columbus, OH 43205 USA

[2] Ohio State Univ, Columbus, OH 43210 USA

[3] Nationwide Childrens Hosp, Div Infect Dis, Dept Pediat, Columbus, OH 43205 USA

[4] Ohio State Univ, Coll Med, Columbus, OH 43210 USA

[5] Malaga Univ, Dept Pediat & Pharmacol, Malaga Med Sch UMA, Malaga, Spain

来源：

CURRENT OPINION IN VIROLOGY | 2021年 / 51卷

关键词：

RECOMBINANT BCG VACCINE; YOUNG-CHILDREN; INFANTS; DISEASE; ANTIBODY; RISK; REINFECTION; IMMUNITY; BURDEN; SINGLE;

D O I：

10.1016/j.coviro.2021.10.012

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Respiratory syncytial virus (RSV) infections result in significant morbidity and mortality for young children worldwide. The development of preventive strategies for RSV has faced different challenges, including the legacy of the first vaccine attempt, and an incomplete understanding of the host immune response to the virus. However, promising preventive strategies against RSV are in the pipeline and their development has advanced rapidly in the past decade due in part to our improved knowledge about the structural conformation of key RSV proteins. These strategies include monoclonal antibodies and different vaccines platforms directed towards the main target populations.

引用

页码：216 / 223

页数：8

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