Don't edit the human germ line

被引：328

作者：

Lanphier, Edward ^{[1
,2
]}

Urnov, Fyodor ^{[1
]}

Haecker, Sarah Ehlen ^{[3
]}

Werner, Michael ^{[2
]}

Smolenski, Joanna ^{[4
]}

机构：

[1] Sangamo BioSci, Richmond, CA 94804 USA

[2] Alliance Regenerat Med, Washington, DC USA

[3] Alliance Regenerat Med, Technol Sect, Washington, DC USA

[4] CUNY, Grad Ctr, Philosophy, New York, NY USA

来源：

NATURE | 2015年 / 519卷 / 7544期

关键词：

RATS;

D O I：

10.1038/519410a

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Heritable human genetic modifications pose serious risks, and the therapeutic benefits are tenuous, warn Edward Lanphier, Fyodor Urnov and colleagues.

引用

页码：410 / 411

页数：2

共 9 条

[1] Genome Engineering with Targetable Nucleases [J].

Carroll, Dana .

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 83, 2014, 83 :409-439

[2] Knockout Rats via Embryo Microinjection of Zinc-Finger Nucleases [J].

Geurts, Aron M. ;

Cost, Gregory J. ;

Freyvert, Yevgeniy ;

Zeitler, Bryan ;

Miller, Jeffrey C. ;

Choi, Vivian M. ;

Jenkins, Shirin S. ;

Wood, Adam ;

Cui, Xiaoxia ;

Meng, Xiangdong ;

Vincent, Anna ;

Lam, Stephen ;

Michalkiewicz, Mieczyslaw ;

Schilling, Rebecca ;

Foeckler, Jamie ;

Kalloway, Shawn ;

Weiler, Hartmut ;

Menoret, Severine ;

Anegon, Ignacio ;

Davis, Gregory D. ;

Zhang, Lei ;

Rebar, Edward J. ;

Gregory, Philip D. ;

Urnov, Fyodor D. ;

Jacob, Howard J. ;

Buelow, Roland .

SCIENCE, 2009, 325 (5939) :433-433

[3] One-step generation of myostatin gene knockout sheep via the CRISPR/Cas9 system [J].

Han, Hongbing ;

Ma, Yonghe ;

Wang, Tao ;

Lian, Ling ;

Tian, Xiuzhi ;

Hu, Rui ;

Deng, Shoulong ;

Li, Kongpan ;

Wang, Feng ;

Li, Ning ;

Liu, Guoshi ;

Zhao, Yaofeng ;

Lian, Zhengxing .

FRONTIERS OF AGRICULTURAL SCIENCE AND ENGINEERING, 2014, 1 (01) :2-5

[4] CRISPR/Cas9 Nuclease-Mediated Gene Knock-In in Bovine-Induced Pluripotent Cells [J].

Heo, Young Tae ;

Quan, Xiaoyuan ;

Xu, Yong Nan ;

Baek, Soonbong ;

Choi, Hwan ;

Kim, Nam-Hyung ;

Kim, Jongpil .

STEM CELLS AND DEVELOPMENT, 2015, 24 (03) :393-402

[5]

Kang Q., 2014, P 10 WORLD C GEN APP

[6]

Regalado A., 2015, MIT TECH REV

[7] Gene Editing of CCR5 in Autologous CD4 T Cells of Persons Infected with HIV [J].

Tebas, Pablo ;

Stein, David ;

Tang, Winson W. ;

Frank, Ian ;

Wang, Shelley Q. ;

Lee, Gary ;

Spratt, S. Kaye ;

Surosky, Richard T. ;

Giedlin, Martin A. ;

Nichol, Geoff ;

Holmes, Michael C. ;

Gregory, Philip D. ;

Ando, Dale G. ;

Kalos, Michael ;

Collman, Ronald G. ;

Binder-Scholl, Gwendolyn ;

Plesa, Gabriela ;

Hwang, Wei-Ting ;

Levine, Bruce L. ;

June, Carl H. .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 370 (10) :901-910

[8] Genome editing with engineered zinc finger nucleases [J].

Urnov, Fyodor D. ;

Rebar, Edward J. ;

Holmes, Michael C. ;

Zhang, H. Steve ;

Gregory, Philip D. .

NATURE REVIEWS GENETICS, 2010, 11 (09) :636-646

[9] Allele-specific genome editing and correction of disease-associated phenotypes in rats using the CRISPR-Cas platform [J].

Yoshimi, K. ;

Kaneko, T. ;

Voigt, B. ;

Mashimo, T. .

NATURE COMMUNICATIONS, 2014, 5

← 1 →