Studies on the effects of monosodium glutamate on hepatic microsomal lipid peroxidation, calcium, ascorbic acid and glutathione and its dependent enzymes in adult male mice

Daily administration of monosodium glutamate (MSG) to adult male mice subcutaneously, for 6 days, at dose levels of 4 and 8 mg/g body weight, significantly increased lipid peroxidation in the hepatic microsomes, as seen 31 days after the last injection. A highly significant increase was observed in the level of hepatic calcium and ascorbic acid. The glutathione (GSH) content was significantly decreased but the activities of glutathione dependent enzymes like GR, GPX, GSTs were found to be significantly increased. These observations suggested that MSG at dose levels above 4 mg/g body weight induced oxidative stress in hepatic microsomes. Attempts to maintain the redox state of the cell are suggested by increase in the ascorbic acid content and the activities of glutathione dependent enzymes.