Phenolics from the Fruits of Maclura pomifera

Two new compounds, maclurin A (1) and maclurin B (2), and six known ones, ononin (3), pterofuran (4), osajin (5), pomiferin (6), 3,4-dihydroxybenzoic acid (7), and 2,3,4-trihydroxybenzoic acid (8) were isolated from the fruit of Madura pomifera. Compounds 3 and 4 were isolated from the genus for the first time. Structure elucidation was achieved by spectroscopic measurements and by comparison with literature data. Compounds 2-4 exhibited activities against the cancer cell lines A549 and Panc-28 with GI(50) values from 18.1 to 32.2, and 20.6 to 43.5 mu M, respectively. Compounds 2 and 4 also showed cytotoxicity against HCT 116 with GI(50) values of 47.2 and 24.4 mu M, respectively.