Personalized Medicine: Progress and Promise

被引：233

作者：

Chan, Isaac S. ^{[1
,2
,3
]}

Ginsburg, Geoffrey S. ^{[1
,3
]}

机构：

[1] Duke Univ, Ctr Genom Med, Inst Genome Sci & Policy, Durham, NC 27708 USA

[2] Univ N Carolina, Sch Med, Dept Genet, Chapel Hill, NC 27599 USA

[3] Duke Univ, Sch Med, Dept Med, Durham, NC 27710 USA

来源：

ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, VOL 12 | 2011年 / 12卷

关键词：

genomic medicine; pharmacogenomics; translational medicine; clinical decision support; comparative effectiveness research; CLINICAL DECISION-SUPPORT; CORONARY-ARTERY-DISEASE; GENOME-WIDE ASSOCIATION; CELL LUNG-CANCER; METASTATIC BREAST-CANCER; GENE-EXPRESSION PATTERNS; HEPATITIS-C VIRUS; FAMILY-HISTORY; MOLECULAR CLASSIFICATION; LINKAGE DISEQUILIBRIUM;

D O I：

10.1146/annurev-genom-082410-101446

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Personalized medicine is a broad and rapidly advancing field of health care that is informed by each person's unique clinical, genetic, genomic, and environmental information. Personalized medicine depends on multidisciplinary health care teams and integrated technologies (e.g., clinical decision support) to utilize our molecular understanding of disease in order to optimize preventive health care strategies. Human genome information now allows providers to create optimized care plans at every stage of a disease, shifting the focus from reactive to preventive health care. The further integration of personalized medicine into the clinical workflow requires overcoming several barriers in education, accessibility, regulation, and reimbursement. This review focuses on providing a comprehensive understanding of personalized medicine, from scientific discovery at the laboratory bench to integration of these novel ways of understanding human biology at the bedside.

引用

页码：217 / 244

页数：28

共 242 条

[41] Metabolic programming in the pathogenesis of insulin resistance [J].

Devaskar, Sherin U. ;

Thamotharan, Manikkavasagar .

REVIEWS IN ENDOCRINE & METABOLIC DISORDERS, 2007, 8 (02) :105-113

[42] Commentary: Personalized Health Planning and the Patient Protection and Affordable Care Act: An Opportunity for Academic Medicine to Lead Health Care Reform [J].

Dinan, Michaela A. ;

Simmons, Leigh Ann ;

Snyderman, Ralph .

ACADEMIC MEDICINE, 2010, 85 (11) :1665-1668

[43] Clinical Genomic Testing: Getting It Right [J].

Douglas, Pamela S. ;

Ginsburg, Geoffrey S. .

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, 2008, 1 (01) :17-20

[44] Blood gene expression profiling in liver transplant recipients with hepatitis C virus and posttransplantation diabetes mellitus [J].

Driscoll, C. J. ;

Cashion, A. K. ;

Hathaway, D. K. ;

Thompson, C. ;

Conley, Y. ;

Riely, C. ;

Xu, L. ;

Homayouni, R. .

TRANSPLANTATION PROCEEDINGS, 2006, 38 (10) :3646-3648

[45] A computational strategy to analyze label-free temporal bottom-up proteomics data [J].

Du, Xiuxia ;

Callister, Stephen J. ;

Manes, Nathan P. ;

Adkins, Joshua N. ;

Alexandridis, Roxana A. ;

Zeng, Xiaohua ;

Roh, Jung Hyeob ;

Smith, William E. ;

Donohue, Timothy J. ;

Kaplan, Samuel ;

Smith, Richard D. ;

Lipton, Mary S. .

JOURNAL OF PROTEOME RESEARCH, 2008, 7 (07) :2595-2604

[46] Prediction and classification of drug toxicity using probabilistic modeling of temporal metabolic data: The Consortium on Metabonomic Toxicology screening approach [J].

Ebbels, Timothy M. D. ;

Keun, Hector C. ;

Beckonert, Olaf P. ;

Bollard, Mary E. ;

Lindon, John C. ;

Holmes, Elaine ;

Nicholson, Jeremy K. .

JOURNAL OF PROTEOME RESEARCH, 2007, 6 (11) :4407-4422

[47] DNA methylation profiling of human chromosomes 6, 20 and 22 [J].

Eckhardt, Florian ;

Lewin, Joern ;

Cortese, Rene ;

Rakyan, Vardhman K. ;

Attwood, John ;

Burger, Matthias ;

Burton, John ;

Cox, Tony V. ;

Davies, Rob ;

Down, Thomas A. ;

Haefliger, Carolina ;

Horton, Roger ;

Howe, Kevin ;

Jackson, David K. ;

Kunde, Jan ;

Koenig, Christoph ;

Liddle, Jennifer ;

Niblett, David ;

Otto, Thomas ;

Pettett, Roger ;

Seemann, Stefanie ;

Thompson, Christian ;

West, Tony ;

Rogers, Jane ;

Olek, Alex ;

Berlin, Kurt ;

Beck, Stephan .

NATURE GENETICS, 2006, 38 (12) :1378-1385

[48] A Randomized Clinical Trial of Clinical Decision Support in a Rural Community Health Network Serving Lower Income Individuals: Study Design and Baseline Characteristics [J].

Eisenstein, Eric L. ;

Lobach, David F. ;

Kawamoto, Kensaku ;

Edwards, Rex ;

Willis, Janese M. ;

Silvey, Garry M. ;

Anstrom, Kevin J. .

ADVANCES IN INFORMATION TECHNOLOGY AND COMMUNICATION IN HEALTH, 2009, 143 :220-+

[49] The economic implications of noninvasive molecular testing for cardiac allograft rejection [J].

Evans, RW ;

Williams, GE ;

Baron, HM ;

Deng, MC ;

Eisen, HJ ;

Hunt, SA ;

Khan, MM ;

Kobashigawa, JA ;

Marton, EN ;

Mehra, MR ;

Mital, SR .

AMERICAN JOURNAL OF TRANSPLANTATION, 2005, 5 (06) :1553-1558

[50] Genomic Medicine: Genomic Medicine -- An Updated Primer. [J].

Feero, W. Gregory ;

Guttmacher, Alan E. ;

Collins, Francis S. .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 362 (21) :2001-2011

← 1 2 3 4 5 6 7 8 9 10 →