Personalized Medicine: Progress and Promise

被引：226
作者：
Chan, Isaac S. [1 ,2 ,3 ]
Ginsburg, Geoffrey S. [1 ,3 ]
机构：
[1] Duke Univ, Ctr Genom Med, Inst Genome Sci & Policy, Durham, NC 27708 USA
[2] Univ N Carolina, Sch Med, Dept Genet, Chapel Hill, NC 27599 USA
[3] Duke Univ, Sch Med, Dept Med, Durham, NC 27710 USA
来源：
ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, VOL 12 | 2011年 / 12卷
关键词：
genomic medicine; pharmacogenomics; translational medicine; clinical decision support; comparative effectiveness research; CLINICAL DECISION-SUPPORT; CORONARY-ARTERY-DISEASE; GENOME-WIDE ASSOCIATION; CELL LUNG-CANCER; METASTATIC BREAST-CANCER; GENE-EXPRESSION PATTERNS; HEPATITIS-C VIRUS; FAMILY-HISTORY; MOLECULAR CLASSIFICATION; LINKAGE DISEQUILIBRIUM;
D O I：
10.1146/annurev-genom-082410-101446
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Personalized medicine is a broad and rapidly advancing field of health care that is informed by each person's unique clinical, genetic, genomic, and environmental information. Personalized medicine depends on multidisciplinary health care teams and integrated technologies (e.g., clinical decision support) to utilize our molecular understanding of disease in order to optimize preventive health care strategies. Human genome information now allows providers to create optimized care plans at every stage of a disease, shifting the focus from reactive to preventive health care. The further integration of personalized medicine into the clinical workflow requires overcoming several barriers in education, accessibility, regulation, and reimbursement. This review focuses on providing a comprehensive understanding of personalized medicine, from scientific discovery at the laboratory bench to integration of these novel ways of understanding human biology at the bedside.
引用
收藏
页码：217 / 244
页数：28
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