Personalized Medicine: Progress and Promise

被引：233

作者：

Chan, Isaac S. ^{[1
,2
,3
]}

Ginsburg, Geoffrey S. ^{[1
,3
]}

机构：

[1] Duke Univ, Ctr Genom Med, Inst Genome Sci & Policy, Durham, NC 27708 USA

[2] Univ N Carolina, Sch Med, Dept Genet, Chapel Hill, NC 27599 USA

[3] Duke Univ, Sch Med, Dept Med, Durham, NC 27710 USA

来源：

ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, VOL 12 | 2011年 / 12卷

关键词：

genomic medicine; pharmacogenomics; translational medicine; clinical decision support; comparative effectiveness research; CLINICAL DECISION-SUPPORT; CORONARY-ARTERY-DISEASE; GENOME-WIDE ASSOCIATION; CELL LUNG-CANCER; METASTATIC BREAST-CANCER; GENE-EXPRESSION PATTERNS; HEPATITIS-C VIRUS; FAMILY-HISTORY; MOLECULAR CLASSIFICATION; LINKAGE DISEQUILIBRIUM;

D O I：

10.1146/annurev-genom-082410-101446

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Personalized medicine is a broad and rapidly advancing field of health care that is informed by each person's unique clinical, genetic, genomic, and environmental information. Personalized medicine depends on multidisciplinary health care teams and integrated technologies (e.g., clinical decision support) to utilize our molecular understanding of disease in order to optimize preventive health care strategies. Human genome information now allows providers to create optimized care plans at every stage of a disease, shifting the focus from reactive to preventive health care. The further integration of personalized medicine into the clinical workflow requires overcoming several barriers in education, accessibility, regulation, and reimbursement. This review focuses on providing a comprehensive understanding of personalized medicine, from scientific discovery at the laboratory bench to integration of these novel ways of understanding human biology at the bedside.

引用

页码：217 / 244

页数：28

共 242 条

[1]

Abbate Antonio, 2003, Semin Vasc Med, V3, P375

[2]

Abrahams Edward, 2009, J Diabetes Sci Technol, V3, P680

[3] Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling [J].

Alizadeh, AA ;

Eisen, MB ;

Davis, RE ;

Ma, C ;

Lossos, IS ;

Rosenwald, A ;

Boldrick, JG ;

Sabet, H ;

Tran, T ;

Yu, X ;

Powell, JI ;

Yang, LM ;

Marti, GE ;

Moore, T ;

Hudson, J ;

Lu, LS ;

Lewis, DB ;

Tibshirani, R ;

Sherlock, G ;

Chan, WC ;

Greiner, TC ;

Weisenburger, DD ;

Armitage, JO ;

Warnke, R ;

Levy, R ;

Wilson, W ;

Grever, MR ;

Byrd, JC ;

Botstein, D ;

Brown, PO ;

Staudt, LM .

NATURE, 2000, 403 (6769) :503-511

[4]

[Anonymous], 2006, AT HOM GEN TESTS HLT

[5]

[Anonymous], 2009, IN NAT PRIOR COMP EF

[6] Perceptions of genetic discrimination among at-risk relatives of colorectal cancer patients [J].

Apse, KA ;

Biesecker, BB ;

Giardiello, FM ;

Fuller, BP ;

Bernhardt, BA .

GENETICS IN MEDICINE, 2004, 6 (06) :510-516

[7] Increased CpG methylation of the estrogen receptor gene in BRCA1-linked estrogen receptor-negative breast cancers [J].

Archey, WB ;

McEachern, KA ;

Robson, M ;

Offit, K ;

Vaziri, SAJ ;

Casey, G ;

Borg, Å ;

Arrick, BA .

ONCOGENE, 2002, 21 (46) :7034-7041

[8] Metabolomics Applied to Diabetes Research Moving From Information to Knowledge [J].

Bain, James R. ;

Stevens, Robert D. ;

Wenner, Brett R. ;

Ilkayeva, Olga ;

Muoio, Deborah M. ;

Newgard, Christopher B. .

DIABETES, 2009, 58 (11) :2429-2443

[9] Our genome unveiled [J].

Baltimore, D .

NATURE, 2001, 409 (6822) :814-816

[10] Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease [J].

Barrett, Jeffrey C. ;

Hansoul, Sarah ;

Nicolae, Dan L. ;

Cho, Judy H. ;

Duerr, Richard H. ;

Rioux, John D. ;

Brant, Steven R. ;

Silverberg, Mark S. ;

Taylor, Kent D. ;

Barmada, M. Michael ;

Bitton, Alain ;

Dassopoulos, Themistocles ;

Datta, Lisa Wu ;

Green, Todd ;

Griffiths, Anne M. ;

Kistner, Emily O. ;

Murtha, Michael T. ;

Regueiro, Miguel D. ;

Rotter, Jerome I. ;

Schumm, L. Philip ;

Steinhart, A. Hillary ;

Targan, Stephan R. ;

Xavier, Ramnik J. ;

Libioulle, Cecile ;

Sandor, Cynthia ;

Lathrop, Mark ;

Belaiche, Jacques ;

Dewit, Olivier ;

Gut, Ivo ;

Heath, Simon ;

Laukens, Debby ;

Mni, Myriam ;

Rutgeerts, Paul ;

Van Gossum, Andre ;

Zelenika, Diana ;

Franchimont, Denis ;

Hugot, Jean-Pierre ;

de Vos, Martine ;

Vermeire, Severine ;

Louis, Edouard ;

Cardon, Lon R. ;

Anderson, Carl A. ;

Drummond, Hazel ;

Nimmo, Elaine ;

Ahmad, Tariq ;

Prescott, Natalie J. ;

Onnie, Clive M. ;

Fisher, Sheila A. ;

Marchini, Jonathan ;

Ghori, Jilur .

NATURE GENETICS, 2008, 40 (08) :955-962

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