Methods. aEuro integral Topical ocular prophylaxis must be instituted early after birth. Recommended prophylactic regimen are: 1%% nitrate solution; 1%% tetracycline solution; 1%% erythromycin solution; 2.5%% povidone-iodine solution; and fusidic acid. Results. aEuro integral Evidence suggests better outcomes using 1%% tetracycline solutions even if there is the risk of selecting drug resistant bacteria. However, even the widespread used nitrate solution can cause a chemical conjunctivitis, arguing against its widespread use. Conclusions. aEuro integral Fusidic acid is a relatively new promising therapy even if there are still few data about its use. None of the used regimens has the optimal risk-benefit profile to suggest a widespread use.