Identification of glycerol-3-phosphate dehydrogenase 1 as a tumour suppressor in human breast cancer

被引：31

作者：

Zhou, Cefan ^{[1
,2
]}

Yu, Jing ^{[2
,3
]}

Wang, Ming ^{[4
]}

Yang, Jing ^{[5
]}

Xiong, Hui ^{[6
]}

Huang, Huang ^{[1
]}

Wu, Dongli ^{[2
]}

Hu, Shimeng ^{[2
]}

Wang, Yefu ^{[2
]}

Chen, Xing-Zhen ^{[1
,7
]}

Tang, Jingfeng ^{[1
]}

机构：

[1] Hubei Univ Technol, Inst Biomed & Pharmaceut Sci, Key Lab Fermentat Engn,Hubei Key Lab Ind Microbio, Minist Educ,Hubei Prov Cooperat Innovat Ctr Ind F, Wuhan, Hubei, Peoples R China

[2] Wuhan Univ, Coll Life Sci, State Key Lab Virol, Wuhan, Hubei, Peoples R China

[3] Hubei Canc Hosp, Dept Clin Lab, Wuhan, Hubei, Peoples R China

[4] Wuhan Univ, Dept Clin Lab, Renmin Hosp, Wuhan, Hubei, Peoples R China

[5] Tsinghua Univ, Inst Immunol, Beijing, Peoples R China

[6] XiLi Peoples Hosp, Shenzhen, Guangdong, Peoples R China

[7] Univ Alberta, Fac Med & Dent, Dept Physiol, Membrane Prot Dis Res Grp, Edmonton, AB, Canada

来源：

ONCOTARGET | 2017年 / 8卷 / 60期

基金：

中国国家自然科学基金;

关键词：

prognostic significance; biomarker; cell proliferation; survival; meta-analysis; GENE-EXPRESSION; UP-REGULATION; MICRORNA-370; METABOLISM; OXIDATION; HALLMARK; LIVER; GPD1;

D O I：

10.18632/oncotarget.21087

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In the present study, we found the mRNA expression level of glycerol-3-phosphate dehydrogenase (GPD1) was significantly downregulated in human breast cancer patients. Patients with reduced GPD1 expression exhibited poorer overall metastatic relapse-free survival (p = 0.0013). Further Cox proportional hazard model analysis revealed that the reduced expression of GPD1 is an independent predictor of overall survival in oestrogen receptor-positive (p = 0.0027, HR = 0.91, 95% CI = 0.85-0.97, N = 3,917) and nodal-negative (p = 0.0013, HR = 0.87, 95% CI = 0.80-0.95, N = 2,456) breast cancer patients. We also demonstrated that GPD1 was a direct target of miR-370, which was significantly upregulated in human breast cancer. We further showed that exogenous expression of GPD1 in human MCF-7 and MDA-MB-231 breast cancer cells significantly inhibited cell proliferation, migration, and invasion. Our results, therefore, suggest a novel tumour suppressor function for GPD1 and contribute to the understanding of cancer metabolism.

引用

页码：101309 / 101324

页数：16

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