miRcode: a map of putative microRNA target sites in the long non-coding transcriptome

被引：601

作者：

Jeggari, Ashwini ^{[1
]}

Marks, Debora S. ^{[2
]}

Larsson, Erik ^{[1
]}

机构：

[1] Univ Gothenburg, Sahlgrenska Acad, Inst Biomed, Dept Med Biochem & Cell Biol, SE-40530 Gothenburg, Sweden

[2] Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02115 USA

来源：

BIOINFORMATICS | 2012年 / 28卷 / 15期

基金：

英国医学研究理事会;

关键词：

GENE-EXPRESSION; MESSENGER-RNAS; DIFFERENTIATION; CHROMATIN; CANCER;

D O I：

10.1093/bioinformatics/bts344

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Although small non-coding RNAs, such as microRNAs, have well-established functions in the cell, long non-coding RNAs (lncRNAs) have only recently started to emerge as abundant regulators of cell physiology, and their functions may be diverse. A small number of studies describe interactions between small and lncRNAs, with lncRNAs acting either as inhibitory decoys or as regulatory targets of microRNAs, but such interactions are still poorly explored. To facilitate the study of microRNA-lncRNA interactions, we implemented miRcode: a comprehensive searchable map of putative microRNA target sites across the complete GENCODE annotated transcriptome, including 10 419 lncRNA genes in the current version.

引用

页码：2062 / 2063

页数：2

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