Can gap junctions deliver?

被引：58

作者：

Brink, Peter R. ^{[1
,2
]}

Valiunas, Virginijus ^{[1
,2
]}

Gordon, Chris ^{[1
,2
]}

Rosen, Michael R. ^{[3
,4
]}

Cohen, Ira S. ^{[1
,2
]}

机构：

[1] SUNY Stony Brook, Dept Physiol & Biophys, Stony Brook, NY 11794 USA

[2] SUNY Stony Brook, Inst Mol Cardiol, Stony Brook, NY 11794 USA

[3] Columbia Univ, Dept Pharmacol, New York, NY 10032 USA

[4] Columbia Univ, Dept Pediat, New York, NY 10032 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 2012年 / 1818卷 / 08期

关键词：

Cell based delivery; siRNA; miRNA; Gap junction; Exosomes; Endosomes; MESENCHYMAL STEM-CELLS; SHORT INTERFERING RNA; HUMAN CONNEXIN37; MAMMALIAN-CELLS; RAT CONNEXIN43; CANINE HEART; CHANNELS; SELECTIVITY; SIRNA; PERMEABILITY;

D O I：

10.1016/j.bbamem.2011.09.025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In vivo delivery of small interfering RNAs (siRNAs) to target cells via the extracellular space has been hampered by dilution effects and immune responses. Gap junction-mediated transfer between cells avoids the extracellular space and its associated limitations. Because of these advantages cell based delivery via gap junctions has emerged as a viable alternative for siRNA or miRNA delivery. Here we discuss the advantages and disadvantages of extracellular delivery and cell to cell delivery via gap junction channels composed of connexins. This article is part of a Special Issue entitled: The Communicating junctions, composition, structure and characteristics. (C) 2011 Published by Elsevier B.V.

引用

页码：2076 / 2081

页数：6

共 68 条

[1]

Alisky Joseph M, 2004, Am J Pharmacogenomics, V4, P45, DOI 10.2165/00129785-200404010-00005

[2] Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes [J].

Alvarez-Erviti, Lydia ;

Seow, Yiqi ;

Yin, HaiFang ;

Betts, Corinne ;

Lakhal, Samira ;

Wood, Matthew J. A. .

NATURE BIOTECHNOLOGY, 2011, 29 (04) :341-U179

[3] The influence of surface charges on the conductance of the human connexin37 gap junction channel [J].

Banach, K ;

Ramanan, SV ;

Brink, PR .

BIOPHYSICAL JOURNAL, 2000, 78 (02) :752-760

[4] Monovalent cation permeation through the connexin40 gap junction channel - Cs, Rb, K, Na, Li, TEA, TMA, TBA, and effects of anions Br, Cl, F, acetate, aspartate, glutamate, and NO3 [J].

Beblo, DA ;

Veenstra, RD .

JOURNAL OF GENERAL PHYSIOLOGY, 1997, 109 (04) :509-522

[5] PERMEABILITY OF GAP JUNCTIONS BETWEEN EMBRYONIC CELLS OF FUNDULUS - RE-EVALUATION [J].

BENNETT, MVL ;

SPIRA, ME ;

SPRAY, DC .

DEVELOPMENTAL BIOLOGY, 1978, 65 (01) :114-125

[6] Pathways for degradation of connexins and gap junctions [J].

Berthoud, VA ;

Minogue, PJ ;

Laing, JG ;

Beyer, EC .

CARDIOVASCULAR RESEARCH, 2004, 62 (02) :256-267

[7]

Beyer E C, 1993, Int Rev Cytol, V137C, P1

[8]

Brink PR, 2010, IDRUGS, V13, P383

[9] Human connexin 43 gap junction channel gating: Evidence for mode shifts and/or heterogeneity [J].

Brink, PR ;

Ramanan, SV ;

Christ, GJ .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 1996, 271 (01) :C321-C331

[10] Evidence for heteromeric gap junction channels formed from rat connexin43 and human connexin37 [J].

Brink, PR ;

Cronin, K ;

Banach, K ;

Peterson, E ;

Westphale, EM ;

Seul, KH ;

Ramanan, SV ;

Beyer, EC .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 1997, 273 (04) :C1386-C1396

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