Editorial update on emerging treatments of atopic dermatitis

被引:4
作者
Ong, Peck Y. [1 ]
机构
[1] Univ So Calif, Keck Sch Med, Childrens Hosp Los Angeles, Div Clin Immunol & Allergy,Dept Pediat, Los Angeles, CA 90027 USA
关键词
atopic dermatitis; IL-22; S; aureus; therapy; STAPHYLOCOCCUS-AUREUS; ANTIMICROBIAL PEPTIDES; IL-22; KERATINOCYTES; IMMUNITY; SKIN;
D O I
10.1517/14728214.2012.668884
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Various new agents are in the research pipeline for atopic dermatitis. These include IL-4 receptor antagonist, cis-urocanic acid, kappa-opiod receptor agonist, neurokinin receptor antagonist and antimicrobial peptide. The current review updates the status of these clinical trials and provides insight into other potential molecular targets including IL-22 and TLR-2.
引用
收藏
页码:129 / 133
页数:5
相关论文
共 20 条
  • [11] IL-22-producing "T22" T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17-producing TH17 T cells
    Nograles, Kristine E.
    Zaba, Lisa C.
    Shemer, Avner
    Fuentes-Duculan, Judilyn
    Cardinale, Irma
    Kikuchi, Toyoko
    Ramon, Michal
    Bergman, Reuven
    Krueger, James G.
    Guttman-Yassky, Emma
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2009, 123 (06) : 1244 - 1252
  • [12] Emerging drugs for atopic dermatitis
    Ong, Peck Y.
    [J]. EXPERT OPINION ON EMERGING DRUGS, 2009, 14 (01) : 165 - 179
  • [13] Endogenous antimicrobial peptides and skin infections in atopic dermatitis
    Ong, PY
    Ohtake, T
    Brandt, C
    Strickland, I
    Boguniewicz, M
    Ganz, T
    Gallo, RL
    Leung, DYM
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (15) : 1151 - 1160
  • [14] Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis
    Paternoster, Lavinia
    Standl, Marie
    Chen, Chih-Mei
    Ramasamy, Adaikalavan
    Bonnelykke, Klaus
    Duijts, Liesbeth
    Ferreira, Manuel A.
    Alves, Alexessander Couto
    Thyssen, Jacob P.
    Albrecht, Eva
    Baurecht, Hansjoerg
    Feenstra, Bjarke
    Sleiman, Patrick M. A.
    Hysi, Pirro
    Warrington, Nicole M.
    Curjuric, Ivan
    Myhre, Ronny
    Curtin, John A.
    Groen-Blokhuis, Maria M.
    Kerkhof, Marjan
    Saaf, Annika
    Franke, Andre
    Ellinghaus, David
    Foelster-Holst, Regina
    Dermitzakis, Emmanouil
    Montgomery, Stephen B.
    Prokisch, Holger
    Heim, Katharina
    Hartikainen, Anna-Liisa
    Pouta, Anneli
    Pekkanen, Juha
    Blakemore, Alexandra I. F.
    Buxton, Jessica L.
    Kaakinen, Marika
    Duffy, David L.
    Madden, Pamela A.
    Heath, Andrew C.
    Montgomery, Grant W.
    Thompson, Philip J.
    Matheson, Melanie C.
    Le Souef, Peter
    St Pourcain, Beate
    Smith, George Davey
    Henderson, John
    Kemp, John P.
    Timpson, Nicholas J.
    Deloukas, Panos
    Ring, Susan M.
    Wichmann, H-Erich
    Mueller-Nurasyid, Martina
    [J]. NATURE GENETICS, 2012, 44 (02) : 187 - 192
  • [15] Secreted virulence factor comparison between methicillin-resistant and methicillin-sensitive Staphylococcus aureus, and its relevance to atopic dermatitis
    Schlievert, Patrick M.
    Strandberg, Kristi L.
    Lin, Ying-Chi
    Peterson, Marnie L.
    Leung, Donald Y. M.
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2010, 125 (01) : 39 - 49
  • [16] The role of keratinocytes in defense against infection
    Schroeder, Jens-Michael
    [J]. CURRENT OPINION IN INFECTIOUS DISEASES, 2010, 23 (02) : 106 - 110
  • [17] Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A
    Sonnenberg, Gregory F.
    Nair, Meera G.
    Kirn, Thomas J.
    Zaph, Colby
    Fouser, Lynette A.
    Artis, David
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2010, 207 (06) : 1293 - 1305
  • [18] Targeting the Neurokinin Receptor 1 with Aprepitant: A Novel Antipruritic Strategy
    Staender, Sonja
    Siepmann, Dorothee
    Herrgott, Ilka
    Sunderkoetter, Cord
    Luger, Thomas A.
    [J]. PLOS ONE, 2010, 5 (06):
  • [19] Travers JB, 2011, PEDIAT DERMATOL
  • [20] IL-22 increases the innate immunity of tissues
    Wolk, K
    Kunz, S
    Witte, E
    Friedrich, M
    Asadullah, K
    Sabat, R
    [J]. IMMUNITY, 2004, 21 (02) : 241 - 254