Apolipoprotein E genotype and concomitant clinical features in early-onset Alzheimer's disease

被引：8

作者：

Bronzova, J

vanDuijn, CM

Havekes, LM

deKnijff, P

Van Broeckhoven, C

Hofman, A

机构：

[1] ERASMUS UNIV ROTTERDAM, SCH MED, DEPT EPIDEMIOL & BIOSTAT, 3000 DR ROTTERDAM, NETHERLANDS

[2] ERASMUS UNIV ROTTERDAM, SCH MED, NETHERLANDS INST HLTH SCI, 3000 DR ROTTERDAM, NETHERLANDS

[3] MED UNIV SOFIA, HOSP OBSTET & GYNAECOL, LAB MOLEC PATHOL, SOFIA, BULGARIA

[4] TNO, INST PREVENT & HLTH, GAUBIUS LAB, LEIDEN, NETHERLANDS

[5] UNIV ANTWERP VIB, BORN BUNGE FDN, DEPT BIOCHEM,NEUROGENET LAB, B-2020 ANTWERP, BELGIUM

来源：

JOURNAL OF NEUROLOGY | 1996年 / 243卷 / 06期

关键词：

Alzheimer disease; apolipoprotein E gene;

D O I：

10.1007/BF00900501

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We have studied the relationship between the apolipoprotein E gene (APOE) and the development of myoclonus, tremors, rigidity and seizures in 168 patients with probable early-onset Alzheimer's disease (AD). There was a statistically significantly lower risk of tremor for carriers of the epsilon 4 allele of APOE. This allele was also associated with an increased risk of myoclonus. Our findings suggest that there may be differences in progression and clinical appearance in early-onset AD related to the APOE genotype.

引用

页码：465 / 468

页数：4

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