Mesenchymal stem cells: Revisiting history, concepts, and assays

被引：1170

作者：

Bianco, Paolo ^{[1
,2
]}

Robey, Pamela Gehron ^{[3
]}

Simmons, Paul J. ^{[4
]}

机构：

[1] Univ Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy

[2] Biomed Sci Pk San Raffaele, I-00128 Rome, Italy

[3] Natl Inst Dent & Cranifacial Res, Craniofacial & Skeletal Dis Branch, Dept Hlth & Human Serv, NIH, Bethesda, MD 20892 USA

[4] Univ Texas Hlth Sci Ctr Houston, Brown Fdn Inst Mol Med, Houston, TX 77030 USA

来源：

CELL STEM CELL | 2008年 / 2卷 / 04期

关键词：

D O I：

10.1016/j.stem.2008.03.002

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

The concept of mesenchymal stem cells has gained wide popularity. Despite the rapid growth of the field, uncertainties remain with respect to the defining characteristics of these cells, including their potency and self-renewal. These uncertainties are reflected in a growing tendency to question the very use of the term. This commentary revisits the experimental origin of the concept of the population(s) referred to as mesenchymal stem cells and the experimental framework required to assess their sternness and function.

引用

页码：313 / 319

页数：7

共 48 条

[1]

ALLEN TD, 1978, 2ND S BRIT SOC CELL, P217

[2]

[Anonymous], 1869, J ANAT PHYSIOL

[3] Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche [J].

Arai, F ;

Hirao, A ;

Ohmura, M ;

Sato, H ;

Matsuoka, S ;

Takubo, K ;

Ito, K ;

Koh, GY ;

Suda, T .

CELL, 2004, 118 (02) :149-161

[4]

Barry Frank P., 2003, Birth Defects Research, V69, P250, DOI 10.1002/bdrc.10021

[5] Multipotent cells can be generated in vitro from several adult human organs (heart, liver, and bone marrow) [J].

Beltrami, Antonio R. ;

Cesselli, Daniela ;

Bergamin, Natascha ;

Marcon, Patrizia ;

Rigo, Silvia ;

Puppato, Elisa ;

D'Aurizio, Federica ;

Verardo, Roberto ;

Piazza, Silvano ;

Pignatelli, Angela ;

Poz, Alessandra ;

Baccarani, Umberto ;

Damiani, Daniela ;

Fanin, Renato ;

Mariuzzi, Laura ;

Finato, Nicoletta. ;

Masolini, Paola ;

Burelli, Silvia ;

Belfuzzi, Ottorino ;

Schneider, Claudio ;

Beltrami, Carlo A. .

BLOOD, 2007, 110 (09) :3438-3446

[6] Life in plastic is fantastic [J].

Bianco, Paolo .

BLOOD, 2007, 110 (09) :3090-3090

[7] Skeletal stem cells [J].

Bianco, Paolo ;

Robey, Pamela G. .

DEVELOPMENT, 2015, 142 (06) :1023-1027

[8] Postnatal skeletal stem cells [J].

Bianco, Paolo ;

Kuznetsov, Sergei A. ;

Riminucci, Mara ;

Robey, Pamela Gehron .

ADULT STEM CELLS, 2006, 419 :117-148

[9] Osteoblastic cells regulate the haematopoietic stem cell niche [J].

Calvi, LM ;

Adams, GB ;

Weibrecht, KW ;

Weber, JM ;

Olson, DP ;

Knight, MC ;

Martin, RP ;

Schipani, E ;

Divieti, P ;

Bringhurst, FR ;

Milner, LA ;

Kronenberg, HM ;

Scadden, DT .

NATURE, 2003, 425 (6960) :841-846

[10] MESENCHYMAL STEM-CELLS [J].

CAPLAN, AI .

JOURNAL OF ORTHOPAEDIC RESEARCH, 1991, 9 (05) :641-650

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