Dual inhibition of P-glycoprotein and midkine may increase therapeutic effects of anticancer drugs

被引：5

作者：

Aynacioglu, A. Sukru ^{[1
]}

Bilir, Ayhan ^{[2
]}

Kadomatsu, Kenji ^{[3
]}

机构：

[1] Istanbul Aydin Univ, Dept Med Pharmacol, Med Fac, Florya Main Campus, TR-34295 Istanbul, Turkey

[2] Istanbul Aydin Univ, Dept Histol & Embryol, Med Fac, Florya Main Campus, TR-34295 Istanbul, Turkey

[3] Nagoya Univ, Grad Sch Med, Dept Biochem, Showa Ku, 65 Tsurumai Cho, Nagoya, Aichi 4668550, Japan

来源：

MEDICAL HYPOTHESES | 2017年 / 107卷

基金：

日本学术振兴会;

关键词：

EXPRESSION; RESISTANCE; CARCINOMA; CANCER; MECHANISMS; CELLS;

D O I：

10.1016/j.mehy.2017.07.019

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Multidrug resistance (MDR) to chemotherapy may significantly affect the outcome of cancer treatment. ATP-dependent drug efflux pumps, including P-glycoprotein (P-gp), contribute to the resistance of various chemotherapeutic agents. Overexpression of P-gp in tumor cells induces chemoresistance via pumping the anticancer drugs out of the cells. In addition to taking part in many biological processes such as development, reproduction and repair, midkine (MK) also plays important roles in the pathogenesis of malignant diseases as well as in the regulation of MDR. Although, the mechanisms of action of P-gp and MK are different, overexpression of both proteins prevents the accumulation of many chemotherapeutics in tumor cells, leading to decreased therapeutic effects of anticancer drugs. Therefore, identification of the result of dual inhibition of P-gp and MK in overcoming chemoresistance may enhance the likelihood for a more efficient chemotherapy. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：26 / 28

页数：3

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