Association study on glutathione S-transferase omega 1 and 2 and familial ALS

被引：18

作者：

De Giessen, Elsmarieke Van ^{[1
]}

Fogh, Isabella ^{[1
]}

Gopinath, Sumana ^{[2
]}

Smith, Bradley ^{[1
]}

Hu, Xun ^{[1
]}

Powell, John ^{[1
]}

Andersen, Peter ^{[3
]}

Nicholson, Garth ^{[2
]}

Al Chalabi, Ammar ^{[1
]}

Shaw, Christopher E. ^{[1
]}

机构：

[1] Kings Coll London, Dept Neurol, Inst Psychiat, London SE5 8AF, England

[2] Concord Hosp, Northcott Neurosci Lab, ANZAC Res Inst, Concord, Australia

[3] Umea Univ, Neurol Inst Farmakol & Klin Neurovetenskap, Umea, Sweden

来源：

AMYOTROPHIC LATERAL SCLEROSIS | 2008年 / 9卷 / 02期

基金：

英国医学研究理事会;

关键词：

amyotrophic lateral sclerosis; glutathione S-transferase omega 1; glutathione S-transferase omega 2; age of onset; survival;

D O I：

10.1080/17482960701702553

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Glutathione S-transferase omega 1 and 2 (GSTO1 and 2) protect from oxidative stress, a possible pathogenic mechanism underlying the pathogenesis of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and Alzheimer's disease. Significant association of age of onset in Alzheimer's patients with GSTO1 and 2 had recently been identified, suggesting a possibly similar association with ALS. In this study 12 Hapmap tagged SNPs in GSTO1 and 2 were genotyped in 251 Caucasian British, Australian and Swedish familial ALS (FALS) cases. No association was found for age of onset and survival of FALS in the British and Australian patients. In the Swedish patients, association for age of onset was found with several SNPs (p=0.003-0.048). These results suggest a possible effect of the GSTO1 and 2 locus on age of onset of FALS.

引用

页码：81 / 84

页数：4

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