Anti-Leucine-rich glioma-inactivated Protein 1 antibody-associated encephalitis complicated by minimal change nephrotic syndrome: a case report

被引：0

作者：

Zhang, W-J ^{[1
,2
]}

Gao, N. ^{[2
,3
]}

机构：

[1] Yanan Univ, Dept Neurol, Hosp Yulin City 1, Yulin, Shaanxi, Peoples R China

[2] Yanan Univ, Affiliated Hosp 2, Yulin, Shaanxi, Peoples R China

[3] Yanan Univ, Hosp Yulin City 1, Dept Infect Dis, Yulin, Shaanxi, Peoples R China

来源：

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES | 2022年 / 26卷 / 20期

关键词：

LGI1; Autoimmune encephalitis; Nephrotic syndrome; MCNS; Case report; FACIOBRACHIAL DYSTONIC SEIZURES; COGNITIVE IMPAIRMENT; IMMUNOTHERAPY; DISEASE;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

BACKGROUND: The aim of the study was to summarize the clinical features, diagnosis and treatment of leucine-rich glioma inactivation protein 1 (LGI-1) antibody-associated encephalitis coexistence of minimal change nephrotic syndrome (MCNS), moreover, to strengthen the awareness of the disease. Increasing number of studies describe coexistence of autoimmune encephalitis and other systemic autoimmune diseases. CASE REPORT: Here we report a case of a patient with anti-LGI1 antibody-associated encephalitis, who presented with cognitive dysfunction, faciobrachial dystonic seizures (FBDS), sleep disturbance, and hyponatremia. Treatment with immunoglobulins, corticosteroids, levetiracetam and oxcarbazepine was proven effective for this patient. The patient had a history of MCNS diagnosed by renal biopsy and responded to treatment with low dose of oral corticosteroids. CONCLUSIONS: This case expanded the spectrum of autoimmune comorbidities in patients with anti-LGI1 encephalitis.

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页码：7556 / 7560

页数：5

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