Effects of serotonin injected into the third ventricle on prolactin and growth hormone secretion in Holstein steers

被引：5

作者：

Kasuya, Etsuko ^{[1
]}

Kushibiki, Shiro ^{[2
]}

Yayou, Ken-Ichi ^{[1
]}

Ito, Shuichi ^{[3
]}

Saito, Toshiyuki ^{[1
]}

Hodate, Koichi ^{[4
]}

Sutoh, Madoka ^{[2
]}

机构：

[1] Natl Inst Agrobiol Sci, Neurobiol Res Unit, Tsukuba, Ibaraki 3058602, Japan

[2] Natl Inst Livestock & Grassland Sci, Tsukuba, Ibaraki, Japan

[3] Kyushu Tokai Univ, Dept Anim Sci, Minamiaso, Japan

[4] Kitasato Univ, Sch Vet Med, Towada, Aomori, Japan

来源：

ANIMAL SCIENCE JOURNAL | 2008年 / 79卷 / 03期

关键词：

growth hormone; prolactin; serotonin; steer; third ventricle;

D O I：

10.1111/j.1740-0929.2008.00538.x

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

In order to clarify the role of serotonin (5-HT) in the regulation of pituitary hormones, the effects of 5-HT injected into the third ventricle (3V) on prolactin (PRL) and growth hormone (GH) release were investigated in Holstein steers. A chronic cannula was implanted in 3V by stereotaxic surgery under general anesthesia. After sufficient recovery from surgery, 5-HT (0, 0.1, 1.0, 2.0 mg) was injected into via the cannula and blood samples were collected over 4 h. Plasma PRL and GH concentrations were determined by radioimmunoassay. PRL release was significantly stimulated by the injection of 5-HT. The increase in PRL was observed at 20 min after the injection at three doses and the highest dose (2.0 mg) was the most effective in stimulating PRL release. The injection of 5-HT into 3V, at all doses tested, did not alter GH release significantly. Our results suggest that 5-HT is involved in the regulation of PRL release partly through the hypothalamus in cattle.

引用

页码：362 / 367

页数：6

共 29 条

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