DNA methylation-derived systemic inflammation indices and their association with oropharyngeal cancer risk and survival

被引：2
作者：
Yang, Bo [1 ]
Eliot, Melissa [1 ]
McClean, Michael D. [2 ]
Waterboer, Tim [3 ]
Pawlita, Michael [3 ]
Butler, Rondi [1 ]
Nelson, Heather H. [4 ,5 ]
Langevin, Scott M. [6 ]
Christensen, Brock C. [7 ,8 ]
Kelsey, Karl T. [1 ,9 ]
机构：
[1] Brown Univ, Dept Epidemiol, 70 Ship St, Providence, RI 02912 USA
[2] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA
[3] German Canc Res Ctr, Div Infect & Canc Epidemiol, Heidelberg, Germany
[4] Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA
[5] Univ Minnesota, Dept Epidemiol & Community Hlth, Minneapolis, MN USA
[6] Univ Cincinnati, Coll Med, Dept Environm & Publ Hlth Sci, Cincinnati, OH USA
[7] Geisel Sch Med Dartmouth, Dept Epidemiol Mol & Syst Biol, Lebanon, NH USA
[8] Geisel Sch Med Dartmouth, Dept Community & Family Med, Lebanon, NH USA
[9] Brown Univ, Dept Pathol & Lab Med, Providence, RI 02912 USA
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2022年 / 44卷 / 04期
关键词：
DNA methylation; head and neck cancer; lymphocyte-to-monocyte ratio; neutrophil-to-lymphocyte ratio; oropharyngeal cancer; SQUAMOUS-CELL CARCINOMA; TO-LYMPHOCYTE RATIO; INDEPENDENT PROGNOSTIC-FACTOR; HUMAN-PAPILLOMAVIRUS; NECK-CANCER; MONOCYTE RATIO; ABSOLUTE COUNTS; ADVANCED HEAD; NEUTROPHIL; PLATELET;
D O I：
10.1002/hed.26981
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Background Head and neck squamous cell carcinomas are associated with systemic inflammation (SI). We evaluated whether DNA methylation-derived SI (mdSI) indices are associated with oropharyngeal cancer risk and survival. Methods Ninety-four oropharyngeal squamous cell carcinoma (OPSCC) cases and 57 controls with DNA methylation data were included. Logistic regression analysis and survival analysis were performed to test the association of mdSI indices with OPSCC risk and survival. Results Higher methylation-derived neutrophil-to-lymphocyte ratio (mdNLR) was associated with increased risk of OPSCC (OR = 1.21, 95%CI: 1.11-1.40) while no association was found with methylation-derived lymphocyte-to-monocyte ratio (mdLMR). For 5-year overall survival, higher mdLMR was significantly associated with decreased risk of death (HR = 0.25, 95%CI: 0.10-0.64) while the converse was observed for mdNLR (HR = 2.48, 95%CI: 1.04-5.92). Conclusion We observed an association between mdSI indices and OPSCC risk and 5-year overall survival. It is possible to use mdLMR as an independent prognostic factor for OPSCC.
引用
收藏
页码：904 / 913
页数：10
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