Short report: Pharmacokinetics of dihydroartemisinin in a murine malaria model

被引：15

作者：

Batty, Kevin T. ^{[1
]}

Gibbons, Peter L.

Davis, Timothy M. E.

Ilett, Kenneth F.

机构：

[1] Curtin Univ Technol, Sch Pharm, Bentley, WA 6102, Australia

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2008年 / 78卷 / 04期

关键词：

D O I：

10.4269/ajtmh.2008.78.641

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Pharmacokinetic properties of dihydroartemisinin (DHA) were determined in mice given 100 mg/kg intraperitoneal DHA. Half-life, CL/F, and V/F were 25 min, 61.3 L/hr/kg, and 36.3 L/kg in malaria-infected mice and 19 min, 50.9 Uhr/kg, and 23.0 L/kg in controls. These data are valuable for pharmacokinetic-pharmacodynamic evaluations of DHA in murine models.

引用

页码：641 / 642

页数：2

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