Remission-induction therapies for early rheumatoid arthritis: evidence to date and clinical implications

被引：23

作者：

Espinoza, Francisco ^{[2
]}

Fabre, Sylvie ^{[1
]}

Pers, Yves-Marie ^{[1
]}

机构：

[1] CHU Lapeyronie, Clin Immunol & Osteoarticular Dis Therapeut Unit, 371 Ave Doyen Gaston Giraud, F-34295 Montpellier, France

[2] Univ Los Andes, Sch Med, Dept Rheumatol, Santiago, Chile

来源：

THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE | 2016年 / 8卷 / 04期

关键词：

disease-modifying antirheumatic drugs; early rheumatoid arthritis; predictive factors; remission; rheumatoid arthritis; MODIFYING ANTIRHEUMATIC DRUGS; CONTROL TREATMENT STRATEGY; COMBINATION DMARD THERAPY; TREAT-TO-TARGET; DOUBLE-BLIND; RHEUMATOLOGY/EUROPEAN LEAGUE; RADIOGRAPHIC PROGRESSION; EULAR RECOMMENDATIONS; PROGNOSTIC-FACTORS; PLUS METHOTREXATE;

D O I：

10.1177/1759720X16654476

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent guidelines on rheumatoid arthritis (RA) point to the importance of achieving remission as soon as possible during the course of the disease. The appropriate use of antirheumatic drugs is critical, particularly in early RA patients, before 24 weeks, since this is a window of opportunity' for treatment to modify disease progression. A treat-to-target strategy added to an aggressive therapeutic approach increases the chance of early remission, particularly in early RA patients. We conducted an overview of current therapeutic strategies leading to remission in early RA patients. We also provide interesting predictive factors that can guide the RA management strategy with regard to disease-modifying treatment and/or drug-free remission.

引用

页码：107 / 118

页数：12

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