Biologic Therapies Targeting Eosinophils: Current Status and Future Prospects

被引：75
作者：
Legrand, Fanny [1 ]
Klion, Amy D. [1 ]
机构：
[1] NIAID, Parasit Dis Lab, Human Eosinophil Sect, NIH, Bethesda, MD 20892 USA
来源：
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE | 2015年 / 3卷 / 02期
基金：
美国国家卫生研究院;
关键词：
Hypereosinophilic syndrome; Eosinophilic gastrointestinal disorders; Asthma; mAb; Mepolizumab; Reslizumab; Benralizumab; CHURG-STRAUSS-SYNDROME; HUMANIZED MONOCLONAL-ANTIBODY; PLACEBO-CONTROLLED TRIAL; RECEPTOR-ALPHA; SEVERE ASTHMA; MEPOLIZUMAB THERAPY; SPUTUM EOSINOPHILIA; PERSISTENT ASTHMA; ATOPIC-DERMATITIS; DOUBLE-BLIND;
D O I：
10.1016/j.jaip.2015.01.013
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
The recent explosion in the number of biologic therapies in clinical development for the treatment of eosinophilic disorders is unprecedented. As these agents become available for clinical use, the selection of the most appropriate agent for a given patient will become increasingly complicated. The aims of this review were 2-fold: (1) to present the lessons learned from clinical trials using the first generation of eosinophil-targeted biologics (antieIL-5 antibodies) and (2) to discuss the advantages and potential limitations of currently available and novel targeted therapies to treat eosinophilic disorders. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology
引用
收藏
页码：167 / 174
页数：8
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