Expression of MMP-2 and MMP-9 in helth endometrium and in chronic endometritis of mares

被引：0

作者：

Porto, C. D. ^{[2
]}

Nunes, L. C. ^{[1
,3
]}

Masseno, A. P. B. ^{[1
]}

Sequeira, J. L. ^{[1
]}

Oliveira, D. E. ^{[4
]}

Alvarenga, M. A. ^{[1
]}

机构：

[1] UNESP, Fac Med Vet & Zootecnia, Botucatu, SP, Brazil

[2] Fac Integrado, Campo Mourao, PR, Brazil

[3] UFES, Ctr Ciencias Agr, Alegre, ES, Brazil

[4] UNESP, Fac Med, Botucatu, SP, Brazil

来源：

ARQUIVO BRASILEIRO DE MEDICINA VETERINARIA E ZOOTECNIA | 2011年 / 63卷 / 01期

关键词：

equine; endometrium; inflammation; fibrosis; metalloproteinases; MATRIX-METALLOPROTEINASE-2; METALLOPROTEINASES; FIBROSIS; DISEASE;

D O I：

10.1590/S0102-09352011000100003

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The expression and distribution of matrix metalloproteinases (MMP) 2 and 9 were evaluated in helth endometrium and in chronic endometrites of mares by means of immunohistochemistry method. Sixty endometrial biopsies were utilized. Expression of MMP-2 was observed in vascular wall, stromal cells, and glandular epithelium. More intense immune reaction was seen in glandular epithelial cells in category III endometritis and in vascular wall in category I endometrium. MMP-9 immune reaction was diffuse and was seen in luminal and glandular epithelium; vascular wall region; and stromal, endotelial, and inflammatory cells. There was a decreased of the immunohistochemical marking in vascular wall region as increased the degree of endometrial injury, as well as reducing the intensity of reaction in this compartment. There was no relation in immunohistochemistry expression of metalloproteinases with the type of endometritis.

引用

页码：12 / 19

页数：8

共 16 条

[1] Gelatinases (MMP-2 and MMP-9) are preferentially expressed by Th1 vs. Th2 cells [J].