Maternal arsenic exposure and nonsyndromic orofacial clefts

被引:15
作者
Suhl, Jonathan [1 ]
Leonard, Stephanie [2 ]
Weyer, Peter [3 ]
Rhoads, Anthony [1 ]
Siega-Riz, Anna Maria [4 ]
Anthony, T. Renee [2 ]
Burns, Trudy L. [1 ]
Conway, Kristin M. [1 ]
Langlois, Peter H. [5 ]
Romitti, Paul A. [1 ]
机构
[1] Univ Iowa, Dept Epidemiol, Coll Publ Hlth, 145 N Riverside Dr,S416 CPHB, Iowa City, IA 52242 USA
[2] Univ Iowa, Dept Occupat & Environm Hlth, Iowa City, IA 52242 USA
[3] Univ Iowa, Ctr Hlth Effects Environm Contaminat, Iowa City, IA 52242 USA
[4] Univ Virginia, Dept Publ Hlth Sci, Charlottesville, VA USA
[5] Texas Dept State Hlth Serv, Birth Defects Epidemiol & Surveillance Branch, Austin, TX USA
来源
BIRTH DEFECTS RESEARCH | 2018年 / 110卷 / 19期
关键词
Arsenic; Cleft Lip; Cleft Palate; Metal; Pregnancy; NEURAL-TUBE DEFECTS; FOOD FREQUENCY QUESTIONNAIRE; BIRTH-DEFECTS; SODIUM ARSENATE; DRINKING-WATER; DEVELOPMENTAL TOXICITY; ORAL CLEFTS; CONGENITAL-MALFORMATIONS; DIABETES-MELLITUS; NORTH-CAROLINA;
D O I
10.1002/bdr2.1386
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background Methods Arsenic is widely distributed in the environment in both inorganic and organic forms. Evidence from animal studies suggests that maternal inorganic arsenic may lead to the development of orofacial clefts (OFC)s in offspring. This evidence, together with the limited epidemiologic data available, supports the need for a comprehensive examination of major sources of arsenic exposure and OFCs in humans. Using interview data collected in the National Birth Defects Prevention Study, public and well water arsenic sampling data, and dietary arsenic estimates, we compared expert-rater assessed occupational arsenic exposure, individual-level exposure to arsenic through drinking water, and dietary arsenic exposure between mothers of OFC cases (N = 435) and unaffected controls (N = 1267). Associations for each source of exposure were estimated for cleft lip +/- palate (CL/P) and cleft palate (CP) using unconditional logistic regression analyses. Results Conclusions Associations for maternal drinking water arsenic exposure and CL/P were near or below unity, whereas those for dietary arsenic exposure tended to be positive. For CP, positive associations were observed for maternal occupational arsenic and inorganic arsenic exposures, with confidence intervals that excluded the null value, whereas those for drinking water or dietary arsenic exposures tended to be near or below unity. Positive associations were observed for maternal occupational arsenic exposure and CP and for maternal dietary arsenic exposure and CL/P; the remainder of associations estimated tended to be near or below unity. Given the exploratory nature of our study, the results should be interpreted cautiously, and continued research using improved exposure assessment methodologies is recommended.
引用
收藏
页码:1455 / 1467
页数:13
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