Chisopanins A-K, 11 new protolimonoids from Chisocheton paniculatus and their anti-inflammatory activities

被引：49
|
作者：
Yang, Ming-Hua [1 ]
Wang, Jun-Song [1 ]
Luo, Jian-Guang [1 ]
Wang, Xiao-Bing [1 ]
Kong, Ling-Yi [1 ]
机构：
[1] China Pharmaceut Univ, Dept Nat Med Chem, Nanjing 210009, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2011年 / 19卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Chisocheton paniculatus; Protolimonoids; Anti-inflammatory activities; MELIA-VOLKENSII MELIACEAE; BIOACTIVE TRITERPENOIDS; PONCIRUS-TRIFOLIATA; CEDRELA-SINENSIS; HIERN MELIACEAE; NITRIC-OXIDE; CONSTITUENTS; TETRANORTRITERPENOIDS; INFLAMMATION; WOOD;
D O I：
10.1016/j.bmc.2011.01.007
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Eleven new protolimonoids, chisopanins A-K (1-11), were isolated from the twigs of Chisocheton paniculatus, as well as thirteen known (12-24) protolimonoids. The structures were elucidated on the basis of spectroscopic analysis, X-ray crystallographic analysis, and chemical methods. Chisopanins A and B (1 and 2) possessing uncommon hemiketal tetrahydropyran ring at C-17 showed the most potent inhibitory activities on lipopolysaccharide-stimulated inflammation factor-release with IC50 values at 5.4 and 7.9 mu M for NO, and at 26.9 and 30.7 mu M for TNF-alpha, respectively. In addition, compounds 5-7, 9, 12, 13, and 20 were potent to inhibit NO production with IC50 value lower than 10 mu M. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1409 / 1417
页数：9
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