Endocannabinoid control of food intake and energy balance

被引：597

作者：

Di Marzo, V ^{[1
]}

Matias, I ^{[1
]}

机构：

[1] CNR, Endocannnabinoid Res Grp, Inst Biomol Chem, I-80078 Naples, Italy

来源：

NATURE NEUROSCIENCE | 2005年 / 8卷 / 05期

关键词：

D O I：

10.1038/nn1457

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Marijuana and its major psychotropic component, Delta(9)-tetrahydrocannabinol, stimulate appetite and increase body weight in wasting syndromes, suggesting that the CB1 cannabinoid receptor and its endogenous ligands, the endocannabinoids, are involved in controlling energy balance. The endocannabinoid system controls food intake via both central and peripheral mechanisms, and it may also stimulate lipogenesis and fat accumulation. Here we discuss the multifaceted regulation of energy homeostasis by endocannabinoids, together with its applications to the treatment of eating disorders and metabolic syndromes.

引用

页码：585 / 589

页数：5

共 66 条

[1] The cannabinoid CB1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured adipocyte cells [J].

Bensaid, M ;

Gary-Bobo, M ;

Esclangon, A ;

Maffrand, JP ;

Le Fur, G ;

Oury-Donat, F ;

Soubrié, P .

MOLECULAR PHARMACOLOGY, 2003, 63 (04) :908-914

[2] Anandamide and diet:: Inclusion of dietary arachidonate and docosahexaenoate leads to increased brain levels of the corresponding N-acylethanolamines in piglets [J].

Berger, A ;

Crozier, G ;

Bisogno, T ;

Cavaliere, P ;

Innis, S ;

Di Marzo, V .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (11) :6402-6406

[3]

Berrendero F, 1999, SYNAPSE, V33, P181, DOI 10.1002/(SICI)1098-2396(19990901)33:3<181::AID-SYN3>3.0.CO

[4]

2-R

[5] Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain [J].

Bisogno, T ;

Howell, F ;

Williams, G ;

Minassi, A ;

Cascio, MG ;

Ligresti, A ;

Matias, I ;

Schiano-Moriello, A ;

Paul, P ;

Williams, EJ ;

Gangadharan, U ;

Hobbs, C ;

Di Marzo, V ;

Doherty, P .

JOURNAL OF CELL BIOLOGY, 2003, 163 (03) :463-468

[6]

Black Shawn C, 2004, Curr Opin Investig Drugs, V5, P389

[7] Expression of cannabinoid CB1 receptors by vagal afferent neurons is inhibited by cholecystokinin [J].

Burdyga, G ;

Lal, S ;

Varro, A ;

Dimaline, R ;

Thompson, DG ;

Dockray, GJ .

JOURNAL OF NEUROSCIENCE, 2004, 24 (11) :2708-2715

[8] Rapid tolerance to the intestinal prokinetic effect of cannabinoid CB1 receptor antagonist, SR 141716 (Rimonabant) [J].

Carai, MAM ;

Colombo, G ;

Gessa, GL .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2004, 494 (2-3) :221-224

[9]

Chambers AP, 2004, PHYSIOL BEHAV, V82, P863, DOI 10.1016/S0031-9384(04)00302-6

[10] Synergistic effects of cannabinoid inverse agonist AM251 and opioid antagonist nalmefene on food intake in mice [J].

Chen, RZ ;

Huang, RRC ;

Shen, CP ;

MacNeil, DJ ;

Fong, TM .

BRAIN RESEARCH, 2004, 999 (02) :227-230

← 1 2 3 4 5 6 7 →