Asymmetric reduction of nitroalkenes with baker's yeast

被引：59

作者：

Kawai, Y ^{[1
]}

Inaba, Y ^{[1
]}

Tokitoh, N ^{[1
]}

机构：

[1] Kyoto Univ, Inst Chem Res, Kyoto 6110011, Japan

来源：

TETRAHEDRON-ASYMMETRY | 2001年 / 12卷 / 02期

关键词：

D O I：

10.1016/S0957-4166(01)00029-5

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Various alpha,beta -disubstituted and trisubstituted nitroalkenes were chemoselectively reduced with baker's yeast to the corresponding nitroalkanes. Stereoselectivities of the reduction of alpha,beta -disubstituted nitroalkenes were modest to low, and e.e.s up to 52% were obtained. Trisubstituted nitroalkenes could be reduced to the corresponding nitroalkanes with excellent enantioselectivities, moderate diastereoselectivities and in good yield. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：309 / 318

页数：10

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