Slow eroding biodegradable multiblock poloxamer copolymers

被引：36

作者：

Ahn, JS ^{[1
]}

Suh, JM ^{[1
]}

Lee, MY ^{[1
]}

Jeong, B ^{[1
]}

机构：

[1] Ewha Womans Univ, Dept Chem, Div Nano Sci, Seoul 120750, South Korea

来源：

POLYMER INTERNATIONAL | 2005年 / 54卷 / 05期

关键词：

block copolymer; micelle; poloxamer; sol-gel transition; thermoreversible gel;

D O I：

10.1002/pi.1780

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Biodegradable multiblock poloxamers (BMPs) with gel duration of 8 h to several weeks were prepared by varying their molecular weights from 4000 to 40 000 g mol(-1). The molecular weight of the BMP was controlled by changing the poloxamer to coupling agent ratio. Assuming a micelle packing model of the BMP gel, as in the case of a poloxamer gel, the micelle properties and critical gel concentration of BMPs were investigated on the basis of the scaling concept. The findings suggest that the control of molecular weight by hydrolyzable groups can be a facile approach to optimize the gel properties for biomedical applications. (c) 2005 Society of Chemical Industry.

引用

页码：842 / 847

页数：6

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