Targeting EGFRvIII for glioblastoma multiforme

被引：49

作者：

Yang, Ju ^{[1
]}

Yan, Jing ^{[1
]}

Liu, Baorui ^{[1
]}

机构：

[1] Nanjing Univ, Clin Canc Inst, Med Sch, Comprehens Canc Ctr,Drum Tower Hosp, Nanjing 210008, Jiangsu, Peoples R China

来源：

CANCER LETTERS | 2017年 / 403卷

关键词：

Glioblastoma; EGFRvIII; Vaccine; CAR T-cell therapy; GROWTH-FACTOR RECEPTOR; CHIMERIC ANTIGEN RECEPTOR; ANTIBODY-DRUG CONJUGATE; T-CELLS; VARIANT III; BISPECIFIC ANTIBODIES; ADJUVANT TEMOZOLOMIDE; PEPTIDE VACCINATION; ANTITUMOR-ACTIVITY; GLIOMA XENOGRAFTS;

D O I：

10.1016/j.canlet.2017.06.024

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Glioblastoma multiforme (GBM) is the most progressive primary brain tumor. Targeting a novel and highly specific tumor antigen is one of the strategies to overcome tumors. EGFR variant III (EGFRvIII) is present in 25%-33% of all patients with GBM and is exclusively expressed on tumor tissue cells. Currently, there are various approaches to target EGFRvIII, including CAR T-cell therapy, therapeutic vaccines, antibodies, and Bi-specific T Cell Engager. In this review, we focus on the preclinical and clinical findings of targeting EGFRvIII for GBM. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：224 / 230

页数：7

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