Gut Microbiota Drive Autoimmune Arthritis by Promoting Differentiation and Migration of Peyer's Patch T Follicular Helper Cells

被引：229

作者：

Teng, Fei ^{[1
]}

Klinger, Christina N. ^{[1
]}

Felix, Krysta M. ^{[1
]}

Bradley, C. Pierce ^{[1
]}

Wu, Eric ^{[1
]}

Tran, Nhan L. ^{[1
]}

Umesaki, Yoshinori ^{[3
]}

Wu, Hsin-Jung Joyce ^{[1
,2
]}

机构：

[1] Univ Arizona, Dept Immunobiol, Tucson, AZ 85719 USA

[2] Univ Arizona, Coll Med, Arizona Arthrit Ctr, Tucson, AZ 85719 USA

[3] Yakult Cent Inst, Izumi 5-11, Tokyo, Japan

来源：

IMMUNITY | 2016年 / 44卷 / 04期

关键词：

T(H)17 CELLS; BACTERIA; RESPONSES; IGA; INTERLEUKIN-2; SPECIFICITY;

D O I：

10.1016/j.immuni.2016.03.013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Gut microbiota profoundly affect gut and systemic diseases, but the mechanism whereby microbiota affect systemic diseases is unclear. It is not known whether specific microbiota regulate T follicular helper (Tfh) cells, whose excessive responses can inflict antibody-mediated autoimmunity. Using the K/BxN autoimmune arthritis model, we demonstrated that Peyer's patch (PP) Tfh cells were essential for gut commensal segmented filamentous bacteria (SFB)-induced systemic arthritis despite the production of auto-antibodies predominantly occurring in systemic lymphoid tissues, not PPs. We determined that SFB, by driving differentiation and egress of PP Tfh cells into systemic sites, boosted systemic Tfh cell and auto-antibody responses that exacerbated arthritis. SFB induced PP Tfh cell differentiation by limiting the access of interleukin 2 to CD4(+) T cells, thereby enhancing Tfh cell master regulator Bcl-6 in a dendritic cell-dependent manner. These findings showed that gut microbiota remotely regulated a systemic disease by driving the induction and egress of gut Tfh cells.

引用

页码：875 / 888

页数：14