Highly sensitive and selective non enzymatic electrochemical glucose sensors based on Graphene Oxide-Molecular Imprinted Polymer

Graphene Oxide-Molecular Imprinted Polymer (GO-MIP) based electrochemical sensor was developed for the first time towards enzyme less determination of glucose. This GO-MIP was obtained from a series of fictionalization, polymerization and template molecule introduction/removal during the synthesizing process. The proposed GO-MIP based electrode showed excellent electrocatalytic activity towards glucose oxidation at optimized conditions and possessing detection limit of 0.1 nM with a response time of similar to 2 min. The current response of GO-MIP based glucose sensor was linearly related to the concentration of glucose. The results obtained from the real time usability of electrodes in human blood matches well with commercially available glucose monitors. Further, the reusability of the material is checked up to eight cycles and interference of glucose with ascorbic acid (AA), uric add (UA) and dopamine (DA) were also studied. The obtained results endorse the promising application of GO-MIP towards superior glucose sensing with long term stability. (C) 2017 Elsevier B.V. All rights reserved.