A Facile and General Method for the Encapsulation of Different Types of Imaging Contrast Agents Within Micrometer-Sized Polymer Beads

被引：31

作者：

Bai, Meng-Yi ^{[1
]}

Moran, Christine H. ^{[1
]}

Zhang, Lei ^{[2
]}

Liu, Changjun ^{[1
]}

Zhang, Yu ^{[1
]}

Wang, Lihong V. ^{[1
]}

Xia, Younan ^{[1
]}

机构：

[1] Washington Univ, Dept Biomed Engn, St Louis, MO 63130 USA

[2] Washington Univ, Dept Med, Sch Med, St Louis, MO 63130 USA

来源：

ADVANCED FUNCTIONAL MATERIALS | 2012年 / 22卷 / 04期

关键词：

hollow colloidal particle; contrast agent; encapsulation; HOLLOW PARTICLES; NANOPARTICLES; MICROBUBBLES; MICROSPHERE; EFFICIENCY;

D O I：

10.1002/adfm.201102582

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Polystyrene (PS) hollow beads with holes on the surfaces are employed as containers for quick loading and encapsulation of a variety of contrast enhancement agents: saline solutions for thermoacoustic tomography, iodinated organic compounds for micro-computed tomography, and perfluorooctane for magnetic resonance. Because of the hole on the surface of the PS hollow bead, the contrast agent to be encapsulated could quickly enter the hollow interior via direct flow rather than slow diffusion through the wall. After loading, the hole on the surface is conveniently sealed by annealing the sample at a temperature (e.g., 95 degrees C) slightly above the glass-transition temperature of PS. In vitro methods are also used to investigate the effectiveness of encapsulation by quantifying the contrast enhancement enabled by the contrast agents.

引用

页码：764 / 770

页数：7

共 36 条

[31]

van Vlerken Lilian E, 2006, Expert Opin Drug Deliv, V3, P205, DOI 10.1517/17425247.3.2.205

[32] Autonomic healing of polymer composites [J].

White, SR ;

Sottos, NR ;

Geubelle, PH ;

Moore, JS ;

Kessler, MR ;

Sriram, SR ;

Brown, EN ;

Viswanathan, S .

NATURE, 2001, 409 (6822) :794-797

[33]

WILCOX DL, 1995, MATER RES SOC SYMP P, V372, P3

[34] Controlling liposome blood clearance by surface-grafted polymers [J].

Woodle, MC .

ADVANCED DRUG DELIVERY REVIEWS, 1998, 32 (1-2) :139-152

[35] Synthesis of pH-sensitive hollow polymer microspheres and their application as drug carriers [J].

Yang, Xiaoying ;

Chen, Liting ;

Huang, Bo ;

Bai, Feng ;

Yang, Xinlin .

POLYMER, 2009, 50 (15) :3556-3563

[36] Preparation and characterization of protein C-loaded PLA nanoparticles [J].

Zambaux, MF ;

Bonneaux, F ;

Gref, R ;

Dellacherie, E ;

Vigneron, C .

JOURNAL OF CONTROLLED RELEASE, 1999, 60 (2-3) :179-188

← 1 2 3 4 →