A spiroketal-enol ether derivative from Tanacetum vulgare selectively inhibits HSV-1 and HSV-2 glycoprotein accumulation in Vero cells

被引：27

作者：

Alvarez, Angel L. ^{[1
]}

Habtemariam, Solomon ^{[2
]}

Moneim, Ahmed E. Abdel ^{[1
]}

Melon, Santiago ^{[3
]}

Dalton, Kevin P. ^{[1
]}

Parra, Francisco ^{[1
]}

机构：

[1] Univ Oviedo, Dept Bioquim & Biol Mol, Inst Univ Biotecnol Asturias, E-33006 Oviedo, Spain

[2] Univ Greenwich, Medway Sch Sci, Pharmacognosy Res Labs, Chatham ME4 4TB, Kent, England

[3] Hosp Univ Cent Asturias, Lab Virol, Serv Microbiol, Oviedo, Spain

来源：

ANTIVIRAL RESEARCH | 2015年 / 119卷

关键词：

Antiviral; HSV; Tanacetum; Tansy; Rhizome; Spiroketals; HERPES-SIMPLEX-VIRUS; IN-VITRO; ANTIVIRAL ACTIVITY; PHYLLANTHUS-ORBICULARIS; SESQUITERPENE LACTONES; DRUG-RESISTANCE; INFECTIONS; FLAVONOIDS; COMPOUND; EXTRACTS;

D O I：

10.1016/j.antiviral.2015.04.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The inhibitory effects of Tanacetum vulgare rhizome extracts on HSV-1 and HSV-2 in vitro replication were assessed. Unlike extracts obtained from the aerial parts, adsorption inhibition and virucidal activities seemed not to be relevant for the observed antiviral action of tansy rhizome extracts. Instead, the most significant effects were the inhibition of virus penetration and a novel mechanism consisting of the specific arrest of viral gene expression and consequently the decrease of viral protein accumulation within infected cells. Through a bioactivity-guided fractionation protocol we isolated and identified the spiroketal-enol ether derivative (E)-2-(2,4-hexadiynyliden)-1,6-dioxaspiro[4.5]dec-3-ene as the active compound responsible for this inhibitory effect. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：8 / 18

页数：11

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