Differences in Puberty of Girls before and during the COVID-19 Pandemic

In the COVID-19 pandemic, there was an increase in consultations for precocious puberty. We aim to analyze differences in female puberty before and during the COVID-19 pandemic. A cross-sectional analytical study was designed at the Pediatric Endocrinology Clinic of the University Hospital of the Federal University of Maranhao in Sao Luis, Brazil. We included 55 girls with precocious puberty, 22 who started puberty during the pandemic and 33 who started puberty before the pandemic. Clinical, anthropometric, laboratory and imaging variables were compared between groups. Statistics were performed to determine if there was a statistical difference between the groups. Girls with puberty during the pandemic had higher Z-scores for weight (1.08 +/- 1.29 versus 0.69 +/- 0.83; p = 0.04), lower ovarian volume (1.88 +/- 0.95 versus 3.15 +/- 2.31; p = 0.01), and smaller differences between thelarche noticed by the parents and the diagnosis (6.63 +/- 5.21 versus 12.15 +/- 9.96; p = 0.02). The association between precocious puberty during the pandemic with higher Z-scores for weight, lower ovarian volume, and a reduction in the time between the perception of pubertal findings by parents and the diagnosis suggests the influence of the pandemic on the normal time of puberty.