Biology and applications of small nucleolar RNAs

被引：54

作者：

Bratkovic, Tomaz ^{[2
]}

Rogelj, Boris ^{[1
]}

机构：

[1] Kings Coll London, Dept Clin Neurosci, MRC Ctr Neurodegenerat Res, Inst Psychiat, London SE5 8AF, England

[2] Univ Ljubljana, Fac Pharm, Dept Pharmaceut Biol, Ljubljana 1000, Slovenia

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2011年 / 68卷 / 23期

关键词：

Small nucleolar RNAs; Biogenesis; Alternative splicing; RNA editing; Gene silencing; PRE-RIBOSOMAL-RNA; EFFICIENT TARGET PREDICTION; H/ACA SMALL NUCLEOLAR; NONCODING RNAS; SNORNA GENES; CAJAL BODY; METHYLATION; GUIDE; EXPRESSION; IDENTIFICATION;

D O I：

10.1007/s00018-011-0762-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Small nucleolar RNAs (snoRNAs) constitute a group of non-coding RNAs principally involved in posttranscriptional modification of ubiquitously expressed ribosomal and small nuclear RNAs. However, a number of tissue-specific snoRNAs have recently been identified that apparently do not target conventional substrates and are presumed to guide processing of primary transcripts of protein-coding genes, potentially expanding the diapason of regulatory RNAs that control translation of mRNA to proteins. Here, we review biogenesis of snoRNAs and redefine their function in light of recent exciting discoveries. We also discuss the potential of recombinant snoRNAs to be used in modulation of gene expression.

引用

页码：3843 / 3851

页数：9

共 76 条

[1] snoTARGET shows that human orphan snoRNA targets locate close to alternative splice junctions [J].

Bazeley, Peter S. ;

Shepelev, Valery ;

Talebizadeh, Zohreh ;

Butler, Merlin G. ;

Fedorova, Larisa ;

Filatov, Vadim ;

Fedorov, Alexei .

GENE, 2008, 408 (1-2) :172-179

[2]

Bertrand E, 2004, MOL BIOL INTELL UNIT, P223

[3]

Blackburn E.H., 2011, COLD SPRING HARB PER, P3

[4] Elements essential for accumulation and function of small nucleolar RNAs directing site-specific pseudouridylation of ribosomal RNAs [J].

Bortolin, ML ;

Ganot, P ;

Kiss, T .

EMBO JOURNAL, 1999, 18 (02) :457-469

[5] PHAX and CRM1 are required sequentially to transport U3 snoRNA to nucleoli [J].

Boulon, S ;

Verheggen, C ;

Jady, BE ;

Girard, C ;

Pescia, C ;

Paul, C ;

Ospina, JK ;

Kiss, T ;

Matera, AG ;

Bordonné, M ;

Bertrand, E .

MOLECULAR CELL, 2004, 16 (05) :777-787

[6] The Hsp90 chaperone controls the biogenesis of L7Ae RNPs through conserved machinery [J].

Boulon, Severine ;

Marmier-Gourrier, Nathalie ;

Pradet-Balade, Berengere ;

Wurth, Laurence ;

Verheggen, Celine ;

Jady, Beata E. ;

Rothe, Benjamin ;

Pescia, Christina ;

Robert, Marie-Cecile ;

Kiss, Tamas ;

Bardoni, Barbara ;

Krol, Alain ;

Branlant, Christiane ;

Allmang, Christine ;

Bertrand, Edouard ;

Charpentier, Bruno .

JOURNAL OF CELL BIOLOGY, 2008, 180 (03) :579-595

[7] Human box C/D snoRNAs with miRNA like functions: expanding the range of regulatory RNAs [J].

Brameier, Markus ;

Herwig, Astrid ;

Reinhardt, Richard ;

Walter, Lutz ;

Gruber, Jens .

NUCLEIC ACIDS RESEARCH, 2011, 39 (02) :675-686

[8] CLUSTERING OF MODIFIED NUCLEOTIDES AT THE FUNCTIONAL CENTER OF BACTERIAL RIBOSOMAL-RNA [J].

BRIMACOMBE, R ;

MITCHELL, P ;

OSSWALD, M ;

STADE, K ;

BOCHKARIOV, D .

FASEB JOURNAL, 1993, 7 (01) :161-167

[9] Regulation of serotonin-2C receptor G-protein coupling by RNA editing [J].

Burns, CM ;

Chu, H ;

Rueter, SM ;

Hutchinson, LK ;

Canton, H ;

SandersBush, E ;

Emeson, RB .

NATURE, 1997, 387 (6630) :303-308

[10] Deep-sequencing of human argonaute-associated small RNAs provides insight into miRNA sorting and reveals argonaute association with RNA fragments of diverse origin [J].

Burroughs, Alexander Maxwell ;

Ando, Yoshinari ;

de Hoon, Michiel Jan Laurens ;

Tomaru, Yasuhiro ;

Suzuki, Harukazu ;

Hayashizaki, Yoshihide ;

Daub, Carsten Olivier .

RNA BIOLOGY, 2011, 8 (01) :158-177

← 1 2 3 4 5 6 7 8 →