Biology and applications of small nucleolar RNAs

被引：49
作者：
Bratkovic, Tomaz [2 ]
Rogelj, Boris [1 ]
机构：
[1] Kings Coll London, Dept Clin Neurosci, MRC Ctr Neurodegenerat Res, Inst Psychiat, London SE5 8AF, England
[2] Univ Ljubljana, Fac Pharm, Dept Pharmaceut Biol, Ljubljana 1000, Slovenia
来源：
CELLULAR AND MOLECULAR LIFE SCIENCES | 2011年 / 68卷 / 23期
关键词：
Small nucleolar RNAs; Biogenesis; Alternative splicing; RNA editing; Gene silencing; PRE-RIBOSOMAL-RNA; EFFICIENT TARGET PREDICTION; H/ACA SMALL NUCLEOLAR; NONCODING RNAS; SNORNA GENES; CAJAL BODY; METHYLATION; GUIDE; EXPRESSION; IDENTIFICATION;
D O I：
10.1007/s00018-011-0762-y
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Small nucleolar RNAs (snoRNAs) constitute a group of non-coding RNAs principally involved in posttranscriptional modification of ubiquitously expressed ribosomal and small nuclear RNAs. However, a number of tissue-specific snoRNAs have recently been identified that apparently do not target conventional substrates and are presumed to guide processing of primary transcripts of protein-coding genes, potentially expanding the diapason of regulatory RNAs that control translation of mRNA to proteins. Here, we review biogenesis of snoRNAs and redefine their function in light of recent exciting discoveries. We also discuss the potential of recombinant snoRNAs to be used in modulation of gene expression.
引用
收藏
页码：3843 / 3851
页数：9
相关论文
共 76 条
  • [1] snoTARGET shows that human orphan snoRNA targets locate close to alternative splice junctions
    Bazeley, Peter S.
    Shepelev, Valery
    Talebizadeh, Zohreh
    Butler, Merlin G.
    Fedorova, Larisa
    Filatov, Vadim
    Fedorov, Alexei
    [J]. GENE, 2008, 408 (1-2) : 172 - 179
  • [2] Bertrand E, 2004, MOL BIOL INTELL UNIT, P223
  • [3] Blackburn E.H., 2011, COLD SPRING HARB PER, P3
  • [4] Elements essential for accumulation and function of small nucleolar RNAs directing site-specific pseudouridylation of ribosomal RNAs
    Bortolin, ML
    Ganot, P
    Kiss, T
    [J]. EMBO JOURNAL, 1999, 18 (02) : 457 - 469
  • [5] PHAX and CRM1 are required sequentially to transport U3 snoRNA to nucleoli
    Boulon, S
    Verheggen, C
    Jady, BE
    Girard, C
    Pescia, C
    Paul, C
    Ospina, JK
    Kiss, T
    Matera, AG
    Bordonné, M
    Bertrand, E
    [J]. MOLECULAR CELL, 2004, 16 (05) : 777 - 787
  • [6] The Hsp90 chaperone controls the biogenesis of L7Ae RNPs through conserved machinery
    Boulon, Severine
    Marmier-Gourrier, Nathalie
    Pradet-Balade, Berengere
    Wurth, Laurence
    Verheggen, Celine
    Jady, Beata E.
    Rothe, Benjamin
    Pescia, Christina
    Robert, Marie-Cecile
    Kiss, Tamas
    Bardoni, Barbara
    Krol, Alain
    Branlant, Christiane
    Allmang, Christine
    Bertrand, Edouard
    Charpentier, Bruno
    [J]. JOURNAL OF CELL BIOLOGY, 2008, 180 (03) : 579 - 595
  • [7] Human box C/D snoRNAs with miRNA like functions: expanding the range of regulatory RNAs
    Brameier, Markus
    Herwig, Astrid
    Reinhardt, Richard
    Walter, Lutz
    Gruber, Jens
    [J]. NUCLEIC ACIDS RESEARCH, 2011, 39 (02) : 675 - 686
  • [8] CLUSTERING OF MODIFIED NUCLEOTIDES AT THE FUNCTIONAL CENTER OF BACTERIAL RIBOSOMAL-RNA
    BRIMACOMBE, R
    MITCHELL, P
    OSSWALD, M
    STADE, K
    BOCHKARIOV, D
    [J]. FASEB JOURNAL, 1993, 7 (01) : 161 - 167
  • [9] Regulation of serotonin-2C receptor G-protein coupling by RNA editing
    Burns, CM
    Chu, H
    Rueter, SM
    Hutchinson, LK
    Canton, H
    SandersBush, E
    Emeson, RB
    [J]. NATURE, 1997, 387 (6630) : 303 - 308
  • [10] Deep-sequencing of human argonaute-associated small RNAs provides insight into miRNA sorting and reveals argonaute association with RNA fragments of diverse origin
    Burroughs, Alexander Maxwell
    Ando, Yoshinari
    de Hoon, Michiel Jan Laurens
    Tomaru, Yasuhiro
    Suzuki, Harukazu
    Hayashizaki, Yoshihide
    Daub, Carsten Olivier
    [J]. RNA BIOLOGY, 2011, 8 (01) : 158 - 177
12345678